Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 2/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.34 |
| ▸ | KHK | P50053 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL411900 | 0.88 | PDE9A (0.38) | GPR119SCDTNKSDDB1CRBN | |
| SCHEMBL21058152 | 0.86 | NR3C1 (0.39) | ALDH1A1MAPTTDP1GPR119SCD | |
| SCHEMBL30450183 | 0.82 | MEN1 (0.43) | MEN1ALDH1A1MAPTPKMALOX15 | |
| SCHEMBL15325873 | 0.82 | KDM1A (0.52) | MEN1ALDH1A1MAPTPKMALOX15 | |
| SCHEMBL1871485 | 0.82 | ALDH1A1 (0.50) | MEN1ALDH1A1MAPTPKMALOX15 | |
| SCHEMBL10060682 | 0.82 | MEN1 (0.43) | MEN1ALDH1A1MAPTPKMALOX15 | |
| SCHEMBL21057930 | 0.81 | TEAD1 (0.36) | GPR119SCDTNKSDDB1CRBN | |
| Hydrochloric Acid SCHEMBL15655447 | 0.81 | KDM1A (0.51) | MEN1ALDH1A1MAPTPKMALOX15 | |
| Hydrochloric Acid SCHEMBL30508276 | 0.81 | MEN1 (0.42) | MEN1ALDH1A1MAPTPKMALOX15 | |
| SCHEMBL28439260 | 0.79 | GPR119 (0.38) | GPR119SCDTNKSDDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728219-B1 | SUBSTITUTED PYRROLIDINE AMIDES I | GRUENENTHAL GMBH (DE) | 2022-04-13 | — | — | EP | disclosed |
| EP-3728219-A1 | SUBSTITUTED PYRROLIDINE AMIDES I | Grünenthal GmbH (DE) | 2020-10-28 | — | — | EP | disclosed |
| CN-111556867-A | Substituted pyrrolidine amides I | 格吕伦塔尔有限公司 | 2020-08-18 | — | — | CN | disclosed |
| US-10626106-B2 | Substituted pyrrolidine amides I | GRUENENTHAL GMBH (DE) | 2020-04-21 | — | — | US | disclosed |
| US-20190185455-A1 | Substituted Pyrrolidine Amides I | GRUENENTHAL GMBH (DE) | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10626106-B2 | Substituted pyrrolidine amides I | NR3C1, NR3C2, NR5A1 | MEN1 2976/4885ALDH1A1 814/4885MAPT 4422/4885 |
| US-20190185455-A1 | Substituted Pyrrolidine Amides I | NR3C1, NR3C2, NR5A1 | MEN1 2976/4885ALDH1A1 814/4885MAPT 4422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.