Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | PDE9A | O76083 | 3/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | HTR7 | P34969 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | TNKS | O95271 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL411900 | 0.98 | PDE9A (0.38) | NR3C1PDE9ARXRARXRBRXRG | |
| SCHEMBL21060754 | 0.86 | MEN1 (0.43) | SCDGPR119ALDH1A1MAPTTDP1 | |
| SCHEMBL21057930 | 0.82 | TEAD1 (0.36) | PDE9ASCDGPR119HTR2AHTR7 | |
| SCHEMBL24268646 | 0.81 | NR3C1 (0.39) | NR3C1PDE9ARXRARXRBRXRG | |
| SCHEMBL29200978 | 0.81 | KDM4E (0.49) | NR3C1PDE9ARXRARXRBRXRG | |
| SCHEMBL24282841 | 0.81 | POLB (0.48) | NR3C1PDE9ASCDGPR119KDM4E | |
| SCHEMBL28439260 | 0.80 | GPR119 (0.38) | SCDGPR119HTR2AHTR7KCNH2 | |
| SCHEMBL25045382 | 0.79 | HTR7 (0.39) | NR3C1PDE9ARXRARXRBRXRG | |
| SCHEMBL767811 | 0.79 | RXRA (0.58) | RXRARXRBRXRGALDH1A1 | |
| SCHEMBL21060639 | 0.78 | GPR119 (0.45) | GPR119ALDH1A1HTR2AHTR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12344605-B2 | Substituted pyrrolidine amides II | GRUENENTHAL GMBH (DE) | 2025-07-01 | — | — | US | disclosed |
| US-20220127264-A1 | SUBSTITUTED PYRROLIDINE AMIDES II | GRUENENTHAL GMBH (DE) | 2022-04-28 | — | — | US | disclosed |
| US-20220127264-A1 | SUBSTITUTED PYRROLIDINE AMIDES II | GRUENENTHAL GMBH (DE) | 2022-04-28 | — | — | US | disclosed |
| EP-3728233-B1 | SUBSTITUTED PYRROLIDINE AMIDES II | GRUENENTHAL GMBH (DE) | 2022-04-20 | — | — | EP | disclosed |
| EP-3728233-B1 | SUBSTITUTED PYRROLIDINE AMIDES II | GRUENENTHAL GMBH (DE) | 2022-04-20 | — | — | EP | disclosed |
| CN-111491931-A | Substituted pyrrolidine amides II | 格吕伦塔尔有限公司 | 2020-08-04 | — | — | CN | disclosed |
| US-20190185470-A1 | Substituted Pyrrolidine Amides II | GRUENENTHAL GMBH (DE) | 2019-06-20 | — | — | US | disclosed |
| US-20190185470-A1 | Substituted Pyrrolidine Amides II | GRUENENTHAL GMBH (DE) | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190185470-A1 | Substituted Pyrrolidine Amides II | NR3C1, NR3C2, MC2R | NR3C1 1/4885PDE9A 1517/4885RXRA 587/4885 |
| US-20220127264-A1 | SUBSTITUTED PYRROLIDINE AMIDES II | NR3C1, NR3C2, MC2R | NR3C1 1/4885PDE9A 1517/4885RXRA 587/4885 |
| US-12344605-B2 | Substituted pyrrolidine amides II | NR3C1, NR3C2, MC2R | NR3C1 1/4885PDE9A 1517/4885RXRA 587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.