Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31637720 | 0.83 | ALDH1A1 (0.35) | ALDH1A1KDM4EGAAMAPTHTT | |
| SCHEMBL31637665 | 0.81 | ALDH1A1 (0.36) | ALDH1A1KDM4EGAAMAPTHTT | |
| SCHEMBL16118625 | 0.80 | — | — | |
| SCHEMBL21112766 | 0.80 | IDO1 (0.31) | IDO1 | |
| SCHEMBL23114994 | 0.79 | GAA (0.38) | GAAIDO1 | |
| SCHEMBL24105932 | 0.79 | TSHR (0.43) | ALDH1A1GAARAB9A | |
| SCHEMBL17586261 | 0.78 | HPGDS (0.37) | HTT | |
| SCHEMBL16118629 | 0.78 | KDM4E (0.37) | ALDH1A1KDM4EGAA | |
| SCHEMBL11224012 | 0.78 | KDM4E (0.37) | ALDH1A1KDM4EGAA | |
| SCHEMBL20565421 | 0.75 | ATF4 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4727942-A2 | THIAZOLOPYRIDIN-7(4H)-ONE WRN INHIBITORS | Nimbus Wadjet, Inc. (US) | 2026-04-22 | — | — | EP | disclosed |
| US-12528806-B2 | WRN inhibitors | NIMBUS WADJET, INC. (US) | 2026-01-20 | — | — | US | disclosed |
| US-12421233-B2 | WRN inhibitors | NIMBUS WADJET, INC. (US) | 2025-09-23 | — | — | US | disclosed |
| US-12344609-B2 | WRN inhibitors | NIMBUS WADJET, INC. (US) | 2025-07-01 | — | — | US | disclosed |
| US-20250206738-A1 | WRN INHIBITORS | NIMBUS DISCOVERY, INC. | 2025-06-26 | — | — | US | disclosed |
| WO-2025137599-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. (US) | 2025-06-26 | — | — | WO | disclosed |
| US-20250171440-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-05-29 | — | — | US | disclosed |
| US-20250171441-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-05-29 | — | — | US | disclosed |
| US-20250171442-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-05-29 | — | — | US | disclosed |
| US-20250129069-A1 | TRIAZOLO WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-04-24 | — | — | US | disclosed |
| US-20250034136-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-01-30 | — | — | US | disclosed |
| WO-2024259048-A2 | THIAZOLOPYRIDIN-7(4H)-ONE WRN INHIBITORS | NIMBUS WADJET, INC. (US) | 2024-12-19 | — | — | WO | disclosed |
| EP-3193855-B1 | BICYCLIC COMPOUNDS | RECURIUM IP HOLDINGS LLC (US) | 2021-05-19 | — | — | EP | disclosed |
| US-10975035-B2 | Bicyclic compounds | RECURIUM IP HOLDINGS, LLC (US) | 2021-04-13 | — | — | US | disclosed |
| US-20190233377-A1 | BICYCLIC COMPOUNDS | Zeno Royalties & Milestones, LLC | 2019-08-01 | — | — | US | disclosed |
| US-10308609-B2 | Bicyclic compounds | Zeno Royalties & Milestones, LLC (US) | 2019-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250206738-A1 | WRN INHIBITORS | WRN, BLM, RECQL | ALDH1A1 3002/4885KDM4E 3350/4885GAA 1618/4885 |
| US-20250171440-A1 | WRN INHIBITORS | WRN, BLM, RECQL | ALDH1A1 3196/4885KDM4E 2662/4885GAA 1645/4885 |
| US-20190233377-A1 | BICYCLIC COMPOUNDS | OPRK1, OPRM1, OPRL1 | ALDH1A1 289/4885KDM4E 3294/4885GAA 2697/4885 |
| US-10975035-B2 | Bicyclic compounds | OPRK1, OPRM1, OPRL1 | ALDH1A1 289/4885KDM4E 3294/4885GAA 2697/4885 |
| US-20250171441-A1 | WRN INHIBITORS | WRN, BLM, RECQL | ALDH1A1 3002/4885KDM4E 3350/4885GAA 1618/4885 |
| US-12421233-B2 | WRN inhibitors | WRN, BLM, RECQL | ALDH1A1 3002/4885KDM4E 3350/4885GAA 1618/4885 |
| US-12344609-B2 | WRN inhibitors | WRN, BLM, RECQL | ALDH1A1 3196/4885KDM4E 2662/4885GAA 1645/4885 |
| US-20250034136-A1 | WRN INHIBITORS | WRN, BLM, RECQL | ALDH1A1 3002/4885KDM4E 3350/4885GAA 1618/4885 |
| US-20250129069-A1 | TRIAZOLO WRN INHIBITORS | WRN, BLM, RECQL | ALDH1A1 3394/4885KDM4E 3188/4885GAA 2265/4885 |
| US-20250171442-A1 | WRN INHIBITORS | WRN, BLM, RECQL | ALDH1A1 2905/4885KDM4E 3415/4885GAA 1509/4885 |
| US-10308609-B2 | Bicyclic compounds | OPRK1, OPRM1, OPRL1 | ALDH1A1 289/4885KDM4E 3294/4885GAA 2697/4885 |
| US-12528806-B2 | WRN inhibitors | WRN, RECQL, BLM | ALDH1A1 1817/4885KDM4E 1099/4885GAA 3847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.