Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 3/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | CTSB | P07858 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | KCNJ6 | P48051 | 3/20 | 0.34 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.34 |
| ▸ | KCNJ3 | P48549 | 3/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SMO | Q99835 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL696235 | 1.00 | SMN1; SMN2 (0.35) | SMN1; SMN2CTSSCTSLCTSBCTSK | |
| SCHEMBL696510 | 0.90 | KCNJ6 (0.34) | CTSSCTSLCTSBCTSKKCNJ6 | |
| SCHEMBL2102731 | 0.88 | SMN1; SMN2 (0.38) | SMN1; SMN2CTSSCTSLCTSBCTSK | |
| SCHEMBL697455 | 0.88 | SMN1; SMN2 (0.38) | SMN1; SMN2CTSSCTSLCTSBCTSK | |
| SCHEMBL697524 | 0.85 | AGTR2 (0.43) | CTSSKCNJ6KCNJ5KCNJ3ALDH1A1 | |
| SCHEMBL697523 | 0.85 | AGTR2 (0.43) | CTSSKCNJ6KCNJ5KCNJ3ALDH1A1 | |
| SCHEMBL697525 | 0.85 | AGTR2 (0.43) | CTSSKCNJ6KCNJ5KCNJ3ALDH1A1 | |
| SCHEMBL697368 | 0.83 | CTSS (0.43) | CTSSCTSK | |
| SCHEMBL696518 | 0.82 | ALDH1A1 (0.37) | CTSSALDH1A1 | |
| SCHEMBL2105222 | 0.82 | ALDH1A1 (0.37) | CTSSALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421826-B1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | HOFFMANN LA ROCHE (CH) | 2013-10-23 | — | — | EP | disclosed |
| US-8163793-B2 | Proline derivatives | HOFFMAN-LA ROCHE INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-20100267722-A1 | NOVEL PROLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267722-A1 | NOVEL PROLINE DERIVATIVES | PRAP1, PRR12, SLC6A7 | SMN1; SMN2 3026/4885CTSS 1542/4885CTSL 178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.