SCHEMBL21078683

SCHEMBL21078683

COc1cc(COC(=O)CCC(=O)O[C@@H]2C[C@H](n3cc(C)c(=O)[nH]c3=O)OC2CO)cc(OC)c1OC

nearest known ligand 0.56

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
RNASE1 P07998 1/20 0.56
TOP2A P11388 3/20 0.47
SLC6A2 P23975 1/20 0.47
TK1 P04183 2/20 0.47
TK2 O00142 1/20 0.46
LMNA P02545 2/20 0.45
TSHR P16473 2/20 0.45
ALB P02768 1/20 0.45
PKM P14618 1/20 0.45
BLM P54132 1/20 0.45
PMP22 Q01453 1/20 0.45
CYP2D6 P10635 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21078681 0.90 RNASE1 (0.45) RNASE1TOP2ATK1
SCHEMBL29319148 0.87 RNASE1 (0.60) RNASE1TOP2ASLC6A2TK1TK2
SCHEMBL22984057 0.86 RNASE1 (0.43) RNASE1TOP2ASLC6A2TK1
SCHEMBL22472268 0.86 RNASE1 (0.51) RNASE1SLC6A2TK1TK2
SCHEMBL23914467 0.85 RNASE1 (0.61) RNASE1TOP2ASLC6A2TK1LMNA
SCHEMBL23914022 0.84 RNASE1 (0.57) RNASE1TOP2ASLC6A2TK1TK2
SCHEMBL28626891 0.82 RNASE1 (0.53) RNASE1SLC6A2TK1TK2LMNA
SCHEMBL19407973 0.82 RNASE1 (0.71) RNASE1SLC6A2TK1TK2LMNA
SCHEMBL767324 0.82 RNASE1 (0.68) RNASE1SLC6A2TK1TK2LMNA
SCHEMBL774263 0.82 RNASE1 (0.68) RNASE1SLC6A2TK1TK2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11548910-B2 Oligonucleotide production method NISSAN CHEMICAL CORPORATION (JP) 2023-01-10 US disclosed
US-20190169223-A1 OLIGONUCLEOTIDE PRODUCTION METHOD NISSAN CHEMICAL CORPORATION (JP) 2019-06-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11548910-B2 Oligonucleotide production method RNGTT, OSGEP, PHAX RNASE1 301/4885TOP2A 191/4885SLC6A2 3077/4885
US-20190169223-A1 OLIGONUCLEOTIDE PRODUCTION METHOD RNGTT, OSGEP, PHAX RNASE1 301/4885TOP2A 191/4885SLC6A2 3077/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.