Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 5/20 | 0.33 |
| ▸ | DRD4 | P21917 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CCL2 | P13500 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | GPR3 | P46089 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1436330 | 0.81 | LMNA (0.40) | LMNAALDH1A1SMN1; SMN2TDP1DRD2 | |
| SCHEMBL21065789 | 0.76 | GPR3 (0.44) | LMNAALDH1A1DRD2DRD4MEN1 | |
| SCHEMBL11155913 | 0.68 | BRD4 (0.49) | LMNAALDH1A1SMN1; SMN2TDP1DRD2 | |
| SCHEMBL12629758 | 0.67 | MAOA (0.37) | LMNAALDH1A1SMN1; SMN2TDP1DRD2 | |
| SCHEMBL2687557 | 0.65 | MAOA (0.37) | MEN1KMT2AATMHDAC4HDAC7 | |
| SCHEMBL19255620 | 0.64 | MEN1 (0.49) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL13633898 | 0.64 | NOS1 (0.36) | MEN1KMT2AATM | |
| SCHEMBL13206625 | 0.63 | MEN1 (0.56) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL22623757 | 0.63 | MEN1 (0.56) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2173695 | 0.63 | MEN1 (0.56) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3492464-A1 | INTERMEDIATES FOR PREPARING INHIBITORS OF HEPATITIS C VIRUS | Gilead Sciences, Inc. (US) | 2019-06-05 | — | — | EP | disclosed |