Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | NMT1 | P30419 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372357 | 0.79 | CA1 (0.58) | MAPTLMNACA1CA2L3MBTL1 | |
| SCHEMBL11308756 | 0.79 | SLC40A1 (0.49) | MAPTLMNACA1L3MBTL1SMN1; SMN2 | |
| SCHEMBL2649761 | 0.79 | L3MBTL1 (0.47) | MAPTCA1CA2L3MBTL1GLA | |
| SCHEMBL2371748 | 0.78 | NMT1 (0.56) | MAPTLMNACA1CA2NMT1 | |
| SCHEMBL1512014 | 0.76 | SLC6A9 (0.44) | MAPTLMNACA1CA2L3MBTL1 | |
| SCHEMBL5307516 | 0.76 | CA2 (0.50) | CA1CA2GLACA7CA9 | |
| SCHEMBL30714245 | 0.76 | CA2 (0.50) | CA1CA2GLACA7CA9 | |
| SCHEMBL264514 | 0.76 | LMNA (0.65) | MAPTLMNACA1CA2GLA | |
| SCHEMBL2443419 | 0.75 | CCR2 (0.41) | MAPTLMNACA1CA2L3MBTL1 | |
| SCHEMBL31370992 | 0.75 | CA1 (0.47) | MAPTLMNACA1CA2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019112719-A1 | HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | ANGEX PHARMACEUTICAL, INC. (US) | 2019-06-13 | — | — | WO | disclosed |