Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 6/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL213271 | 0.95 | SCD5 (0.34) | KDM4ELMNANPC1RAB9APOLB | |
| SCHEMBL212588 | 0.94 | MAPT (0.34) | KDM4ETP53LMNAHTTNPC1 | |
| SCHEMBL212860 | 0.93 | KDM4E (0.38) | KDM4ETP53LMNAHTTNPC1 | |
| SCHEMBL212349 | 0.90 | MAPT (0.34) | KDM4ETP53LMNANPC1RAB9A | |
| SCHEMBL210986 | 0.89 | SCD5 (0.35) | KDM4ELMNARAB9APOLBMAPT | |
| SCHEMBL211432 | 0.88 | ALDH1A1 (0.33) | KDM4ETP53LMNAHTTNPC1 | |
| SCHEMBL212145 | 0.88 | KIT (0.31) | — | |
| SCHEMBL212523 | 0.88 | SMN1; SMN2 (0.35) | NPC1RAB9ASMN1; SMN2POLBKMT2A | |
| SCHEMBL2725422 | 0.87 | KDM4E (0.37) | KDM4ETP53LMNAHTTNPC1 | |
| SCHEMBL4350860 | 0.86 | SCD5 (0.35) | KDM4ETP53LMNARAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |