Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.33 |
| ▸ | BRAF | P15056 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL212145 | 0.94 | KIT (0.31) | — | |
| SCHEMBL211532 | 0.93 | SMN1; SMN2 (0.35) | SMN1; SMN2TDP1NPC1RAB9AMAPK14 | |
| SCHEMBL213271 | 0.88 | SCD5 (0.34) | NPC1RAB9ABRAFPOLBMEN1 | |
| SCHEMBL210927 | 0.88 | KDM4E (0.37) | SMN1; SMN2NPC1RAB9APOLBMEN1 | |
| SCHEMBL215012 | 0.87 | KIT (0.30) | — | |
| SCHEMBL2727393 | 0.87 | SMN1; SMN2 (0.35) | SMN1; SMN2TDP1NPC1RAB9APDGFRB | |
| SCHEMBL212588 | 0.86 | MAPT (0.34) | SMN1; SMN2NPC1RAB9APOLBMEN1 | |
| SCHEMBL212349 | 0.84 | MAPT (0.34) | NPC1RAB9ABRAFPOLBMEN1 | |
| SCHEMBL212791 | 0.83 | MAPT (0.40) | SMN1; SMN2NPC1RAB9ABRAFMEN1 | |
| SCHEMBL211083 | 0.83 | CTSK (0.35) | RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |