Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL210927 | 0.94 | KDM4E (0.37) | MAPTTP53POLBRAB9ASMN1; SMN2 | |
| SCHEMBL211432 | 0.94 | ALDH1A1 (0.33) | MAPTTP53ALDH1A1POLBRAB9A | |
| SCHEMBL213271 | 0.94 | SCD5 (0.34) | MAPTALDH1A1POLBRAB9ANPC1 | |
| SCHEMBL212349 | 0.89 | MAPT (0.34) | MAPTTP53ALDH1A1POLBRAB9A | |
| SCHEMBL212860 | 0.88 | KDM4E (0.38) | MAPTTP53POLBRAB9ASMN1; SMN2 | |
| SCHEMBL210986 | 0.88 | SCD5 (0.35) | MAPTALDH1A1POLBRAB9AMEN1 | |
| SCHEMBL2725869 | 0.87 | MAPT (0.34) | MAPTTP53ALDH1A1POLBRAB9A | |
| SCHEMBL212145 | 0.86 | KIT (0.31) | — | |
| SCHEMBL212523 | 0.86 | SMN1; SMN2 (0.35) | POLBRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL212054 | 0.86 | CSNK2A2 (0.38) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |