SCHEMBL21111050

SCHEMBL21111050

O=C(Nc1ccc(C(F)(F)F)cc1)c1ccc(C(F)(F)F)cc1NS(=O)(=O)C(F)(F)F

nearest known ligand 0.52

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GPR27 Q9NS67 5/20 0.52
AVPR2 P30518 4/20 0.52
TRPV1 Q8NER1 3/20 0.52
P2RX1 P51575 1/20 0.49
P2RX4 Q99571 1/20 0.49
P2RX7 Q99572 1/20 0.49
TMPRSS4 Q9NRS4 1/20 0.49
PTGS1 P23219 3/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
RXFP1 Q9HBX9 1/20 0.48
JAK2 O60674 1/20 0.48
JAK1 P23458 1/20 0.48
TYK2 P29597 1/20 0.48
NPC1 O15118 1/20 0.48
RAB9A P51151 1/20 0.48
MAPK1 P28482 1/20 0.47
EPHX2 P34913 1/20 0.46
F10 P00742 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2080103 0.83 ACLY (0.49) GPR27AVPR2SMN1; SMN2RXFP1MAPK1
SCHEMBL22892726 0.82 NFKB1 (0.54) GPR27AVPR2TRPV1P2RX1P2RX4
SCHEMBL21111044 0.82 ACLY (0.64)
SCHEMBL22954241 0.80 PTGS1 (0.45) TRPV1PTGS1SMN1; SMN2NPC1RAB9A
SCHEMBL22954260 0.80 KCNQ3 (0.52) GPR27AVPR2TRPV1P2RX1P2RX4
SCHEMBL22954242 0.79 XPO1 (0.51) GPR27AVPR2P2RX1P2RX4P2RX7
SCHEMBL21111046 0.78 CFTR (0.57) GPR27AVPR2SMN1; SMN2
SCHEMBL13043928 0.75 KDM1A (0.50) SMN1; SMN2RXFP1MAPK1
SCHEMBL27575403 0.75 MEN1 (0.54) SMN1; SMN2RXFP1MAPK1
SCHEMBL27575234 0.75 SLC20A2 (0.57) GPR27AVPR2SMN1; SMN2JAK2TYK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10793520-B2 Sulfonylaminobenzamide compound and pest control agent NIPPON SODA CO., LTD. (JP) 2020-10-06 US disclosed
US-10793520-B2 Sulfonylaminobenzamide compound and pest control agent NIPPON SODA CO., LTD. (JP) 2020-10-06 US disclosed
US-20190225577-A1 SULFONYLAMINOBENZAMIDE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2019-07-25 US disclosed
US-20190225577-A1 SULFONYLAMINOBENZAMIDE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2019-07-25 US disclosed
EP-3508475-A1 SULFONYLAMINO BENZAMIDE COMPOUND AND PEST CONTROL AGENT Nippon Soda Co., Ltd. (JP) 2019-07-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190225577-A1 SULFONYLAMINOBENZAMIDE COMPOUND AND PEST CONTROL AGENT CBR3, CBR1, HRH2 GPR27 2369/4885AVPR2 458/4885TRPV1 628/4885
US-10793520-B2 Sulfonylaminobenzamide compound and pest control agent CBR3, CBR1, HRH2 GPR27 2369/4885AVPR2 458/4885TRPV1 628/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.