Alfaxalone

Alfaxalone

SCHEMBL2111685

CC(=O)C1CCC2C3CCC4CC(O)CCC4(C)C3C(=O)CC12C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GABRA1 P14867 6/20 1.00
▸ GABRB2 P47870 6/20 1.00
▸ G6PD P11413 5/20 1.00
▸ CYP3A4 P08684 4/20 1.00
▸ GABRG2 P18507 4/20 1.00
▸ GABRB3 P28472 4/20 1.00
▸ CYP2C9 P11712 3/20 1.00
▸ GABRA2 P47869 3/20 1.00
▸ MEN1 O00255 2/20 1.00
▸ KMT2A Q03164 2/20 1.00
▸ GLA P06280 1/20 1.00
▸ SMN1; SMN2 Q16637 1/20 1.00
▸ GABRP O00591 2/20 0.70
▸ GABRD O14764 2/20 0.70
▸ GABRB1 P18505 2/20 0.70
▸ GABRA5 P31644 2/20 0.70
▸ GABRA3 P34903 2/20 0.70
▸ GABRA4 P48169 2/20 0.70
▸ GABRE P78334 2/20 0.70
▸ GABRA6 Q16445 2/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Alfaxalone SCHEMBL57756 1.00 GABRA1 (1.00) GABRA1GABRB2G6PDCYP3A4GABRG2
Renanolone SCHEMBL5610376 1.00 GABRA1 (1.00) GABRA1GABRB2G6PDCYP3A4GABRG2
Alfaxalone SCHEMBL9436587 1.00 GABRA1 (1.00) GABRA1GABRB2G6PDCYP3A4GABRG2
Alfaxalone SCHEMBL21614070 1.00 GABRA1 (1.00) GABRA1GABRB2G6PDCYP3A4GABRG2
Alfaxalone SCHEMBL24766358 1.00 GABRA1 (1.00) GABRA1GABRB2G6PDCYP3A4GABRG2
Alfaxalone SCHEMBL21614107 1.00 GABRA1 (1.00) GABRA1GABRB2G6PDCYP3A4GABRG2
Alfaxalone SCHEMBL24675016 1.00 GABRA1 (1.00) GABRA1GABRB2G6PDCYP3A4GABRG2
Alfaxalone SCHEMBL21614053 1.00 GABRA1 (1.00) GABRA1GABRB2G6PDCYP3A4GABRG2
Alfaxalone SCHEMBL24765814 1.00 GABRA1 (1.00) GABRA1GABRB2G6PDCYP3A4GABRG2
Alfaxalone SCHEMBL21614074 1.00 GABRA1 (1.00) GABRA1GABRB2G6PDCYP3A4GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230183238-A1 RING DEUTERATED GABOXADOL AND ITS USE FOR THE TREATMENT OF PSYCHIATRIC DISORDERS CERTEGO ABC, LLC 2023-06-15 — — US claimed
EP-4153549-A2 RING DEUTERATED GABOXADOL AND ITS USE FOR THE TREATMENT OF PSYCHIATRIC DISORDERS Certego Therapeutics Inc. (US) 2023-03-29 — — EP claimed
US-11597726-B2 Ring deuterated gaboxadol and its use for the treatment of psychiatric disorders Certego Therapeutics Inc. (US) 2023-03-07 — — US claimed
US-20220127261-A1 RING DEUTERATED GABOXADOL AND ITS USE FOR THE TREATMENT OF PSYCHIATRIC DISORDERS CERTEGO ABC, LLC 2022-04-28 — — US claimed
US-20220008398-A1 GABOXADOL FOR REDUCING RISK OF SUICIDE AND RAPID RELIEF OF DEPRESSION Certego Therapeutics (US) 2022-01-13 — — US claimed
WO-2021236876-A2 RING DEUTERATED GABOXADOL AND ITS USE FOR THE TREATMENT OF PSYCHIATRIC DISORDERS Certego Therapeutics Inc. (US) 2021-11-25 — — WO claimed
EP-3883566-A1 GABOXADOL FOR REDUCING RISK OF SUICIDE AND RAPID RELIEF OF DEPRESSION Certego Therapeutics Inc. (US) 2021-09-29 — — EP claimed
US-11123332-B2 Gaboxadol for reducing risk of suicide and rapid relief of depression Certego Therapeutics Inc. (US) 2021-09-21 — — US claimed
US-10966965-B2 — — 2021-04-06 — — US claimed
US-20200155522-A1 GABOXADOL FOR REDUCING RISK OF SUICIDE AND RAPID RELIEF OF DEPRESSION Certego Therapeutics (US) 2020-05-21 — — US claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 — — US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 — — US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 — — CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 — — EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 — — WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 — — US claimed
US-12616807-B2 Medical counter measures including dry powder formulations and associated methods Belhaven BioPharma Inc. (US) 2026-05-05 — — US disclosed
WO-2026076495-A1 METHOD OF TREATMENT OR INHIBITION TRKB Investments Pty Ltd (AU) 2026-04-16 — — WO disclosed
US-6264917-B1 MIXTURE OF GAS FILLED MICROBUBBLES AND RELEASING AGENT NYCOMED IMAGING AS (NO) 2001-07-24 — — US disclosed
US-6261537-B1 TARGETS AND ULTRASOUND DIAGNOSIS OF ACTIVE MATERIALS, AQUEOUS CARRIER LIQUIDS, CARRIERS AND FILM FORMING SURFACTANT PHOSPHATIDES NYCOMED IMAGING AS (NO) 2001-07-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230183238-A1 RING DEUTERATED GABOXADOL AND ITS USE FOR THE TREATMENT OF PSYCHIATRIC DISORDERS GABRD, GABRA6, GABRA3 GABRA1 8/4885GABRB2 14/4885G6PD 2073/4885
US-12616807-B2 Medical counter measures including dry powder formulations and associated methods ADRB2, ADRB3, MC5R GABRA1 1034/4885GABRB2 1081/4885G6PD 3208/4885
US-20220127261-A1 RING DEUTERATED GABOXADOL AND ITS USE FOR THE TREATMENT OF PSYCHIATRIC DISORDERS GABRD, GABRA6, GABRA3 GABRA1 8/4885GABRB2 14/4885G6PD 2073/4885
US-11597726-B2 Ring deuterated gaboxadol and its use for the treatment of psychiatric disorders GABRD, GABRA6, GABRA3 GABRA1 8/4885GABRB2 14/4885G6PD 2073/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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