Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21045413 | 0.88 | PDK1 (0.43) | HPGDSMN1; SMN2P2RX7KITPDGFRA | |
| SCHEMBL21045196 | 0.80 | ROCK2 (0.49) | HPGDSMN1; SMN2P2RX7CNR1ROCK2 | |
| SCHEMBL29411659 | 0.80 | ROCK2 (0.49) | HPGDSMN1; SMN2P2RX7CNR1ROCK2 | |
| SCHEMBL21045121 | 0.79 | SMN1; SMN2 (0.43) | HPGDSMN1; SMN2P2RX7CNR1ROCK2 | |
| SCHEMBL29411490 | 0.77 | SMN1; SMN2 (0.49) | HPGDSMN1; SMN2P2RX7CNR1MEN1 | |
| SCHEMBL21045225 | 0.77 | SMN1; SMN2 (0.49) | HPGDSMN1; SMN2P2RX7CNR1MEN1 | |
| SCHEMBL21045126 | 0.77 | FLT3 (0.54) | — | |
| SCHEMBL21100474 | 0.74 | P2RX7 (0.42) | HPGDSMN1; SMN2P2RX7CNR1ROCK2 | |
| SCHEMBL21045267 | 0.73 | DHODH (0.48) | HPGDSMN1; SMN2P2RX7MEN1KMT2A | |
| SCHEMBL29411513 | 0.73 | DHODH (0.48) | HPGDSMN1; SMN2P2RX7MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11040945-B2 | Tubulin inhibitors | LIN BIOSCIENCE PTY LTD. | 2021-06-22 | — | — | US | disclosed |
| US-20190169127-A1 | TUBULIN INHIBITORS | LIN BIOSCIENCE INC. (TW) | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11040945-B2 | Tubulin inhibitors | TUBB3, TUBB1, TUBB | HPGD 3869/4885SMN1; SMN2 1062/4885P2RX7 4844/4885 |
| US-20190169127-A1 | TUBULIN INHIBITORS | TUBB3, TUBB1, TUBB | HPGD 3869/4885SMN1; SMN2 1062/4885P2RX7 4844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.