Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21305080 | 0.68 | BRD4 (0.41) | CCR8KMT2AKDM4EMAOAMAOB | |
| SCHEMBL16177477 | 0.66 | CCR8 (0.54) | CCR8KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL21564019 | 0.64 | CCR8 (0.59) | CCR8KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4426880 | 0.64 | TNF (0.39) | MAOAMAOB | |
| SCHEMBL660982 | 0.64 | PARP1 (0.42) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4240700 | 0.64 | CCR8 (0.46) | CCR8KMT2ALMNAKDM4EMEN1 | |
| SCHEMBL30774416 | 0.62 | CCR8 (1.00) | CCR8KMT2ALMNAKDM4EALDH1A1 | |
| SCHEMBL19318056 | 0.62 | CCR8 (1.00) | CCR8KMT2ALMNAKDM4EALDH1A1 | |
| SCHEMBL4416677 | 0.60 | KCNA3 (0.32) | — | |
| SCHEMBL4426311 | 0.59 | KCNA3 (0.31) | ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12134602-B2 | (−)-huperzine A processes and related compositions and methods of treatment | YALE UNIVERSITY (US) | 2024-11-05 | — | — | US | disclosed |
| US-20220064123-A1 | (--)-Huperzine A Processes and Related Compositions and Methods of Treatment | UNIV YALE (US) | 2022-03-03 | — | — | US | disclosed |
| US-11142503-B2 | (−)-huperzine A processes and related compositions and methods of treatment | YALE UNIVERSITY (US) | 2021-10-12 | — | — | US | disclosed |
| US-20200392086-A1 | (--)-Huperzine A Processes and Related Compositions and Methods of Treatment | UNIV YALE (US) | 2020-12-17 | — | — | US | disclosed |
| EP-3434669-B1 | INTERMEDIATE COMPOUNDS UTILIZABLE IN SYNTHESIS OF (-) HUPERZINE AND PROCESS FOR OBTAIN ONE OF THESE INTERMEDIATE COMPOUNDS | UNIV YALE (US) | 2020-11-04 | — | — | EP | disclosed |
| US-10781179-B2 | (−)-huperzine A processes and related compositions and methods of treatment | YALE UNIVERSITY (US) | 2020-09-22 | — | — | US | disclosed |
| US-20200223860-A1 | THE TOTAL SYNTHESIS OF GLUCOSEPANE AND RELATED CHEMICAL REACTIONS, COMPOUNDS AND COMPOSITIONS AND OBTAINED THEREFROM AND METHODS OF TREATMENT | UNIV YALE (US) | 2020-07-16 | — | — | US | disclosed |
| CN-106117140-B | (-) -huperzine A methods and related compositions and methods of treatment | 耶鲁大学 | 2020-05-05 | — | — | CN | disclosed |
| US-20200109118-A1 | (--)-HUPERZINE A PROCESSES AND RELATED COMPOSITIONS AND METHODS OF TREATMENT | UNIV YALE (US) | 2020-04-09 | — | — | US | disclosed |
| US-10457643-B2 | (−)-huperzine A processes and related compositions and methods of treatment | YALE UNIVERSITY (US) | 2019-10-29 | — | — | US | disclosed |
| US-20150158817-A1 | (--)-Huperzine A Processes and Related Compositions and Methods of Treatment | YALE UNIVERSITY | 2015-06-11 | — | — | US | disclosed |
| US-20150087886-A1 | NOVEL BIFUNCTIONAL METNASE/INTNASE INHIBITORS AND RELATED COMPOSITIONS AND METHODS OF TREATMENT OF CANCER | THE REGENTS OF THE UNIVERSITY OF NEW MEXICO | 2015-03-26 | — | — | US | disclosed |
| US-8889689-B2 | Bifunctional metnase/intnase inhibitors and related compositions and methods of treatment of cancer | STC.UNM (US) | 2014-11-18 | — | — | US | disclosed |
| US-20140248268-A1 | Rab7 GTPase Inhibitors and Related Methods of Treatment | THE REGENTS OF THE UNIVERSITY OF NEW MEXICO | 2014-09-04 | — | — | US | disclosed |
| US-8765803-B1 | Rab7 GTPase inhibitors and related methods of treatment | STC.UNM (US) | 2014-07-01 | — | — | US | disclosed |
| EP-2681199-A1 | (--)- HUPERZINE A PROCESSES AND RELATED COMPOSITIONS AND METHODS OF TREATMENT | Yale University (US) | 2014-01-08 | — | — | EP | disclosed |
| US-20120302582-A1 | NOVEL BIFUNCTIONAL METNASE/INTNASE INHIBITORS AND RELATED COMPOSITIONS AND METHODS OF TREATMENT OF CANCER | THE REGENTS OF THE UNIVERSITY OF NEW MEXICO | 2012-11-29 | — | — | US | disclosed |
| WO-2012121863-A1 | (--)- HUPERZINE A PROCESSES AND RELATED COMPOSITIONS AND METHODS OF TREATMENT | YALE UNIVERSITY (US) | 2012-09-13 | — | — | WO | disclosed |
| US-20120093917-A1 | METNASE AND INTNASE INHIBITORS AND THEIR USE IN TREATING CANCER | THE REGENTS OF THE UNIVERSITY OF NEW MEXICO | 2012-04-19 | — | — | US | disclosed |
| WO-2010114919-A2 | METNASE AND INTNASE INHIBITORS AND THEIR USE IN TREATING CANCER | STC.UNM (US) | 2010-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10781179-B2 | (−)-huperzine A processes and related compositions and methods of treatment | CHRNA5, HTR2A, GRIK5 | CCR8 4467/4885KMT2A 619/4885LMNA 404/4885 |
| US-20120302582-A1 | NOVEL BIFUNCTIONAL METNASE/INTNASE INHIBITORS AND RELATED COMPOSITIONS AND METHODS OF TREATMENT OF CANCER | POLN, MED16, POLR2E | CCR8 3864/4885KMT2A 319/4885LMNA 288/4885 |
| US-11142503-B2 | (−)-huperzine A processes and related compositions and methods of treatment | CHRNA5, HTR2A, GRIK5 | CCR8 4467/4885KMT2A 619/4885LMNA 404/4885 |
| US-20200392086-A1 | (--)-Huperzine A Processes and Related Compositions and Methods of Treatment | CHRNA5, HTR2A, HTT | CCR8 4590/4885KMT2A 443/4885LMNA 415/4885 |
| US-20150087886-A1 | NOVEL BIFUNCTIONAL METNASE/INTNASE INHIBITORS AND RELATED COMPOSITIONS AND METHODS OF TREATMENT OF CANCER | POLN, MED16, GMNN | CCR8 3969/4885KMT2A 354/4885LMNA 320/4885 |
| US-20140248268-A1 | Rab7 GTPase Inhibitors and Related Methods of Treatment | RAB7A, RAB5B, RAB1A | CCR8 4613/4885KMT2A 4280/4885LMNA 2585/4885 |
| US-20120093917-A1 | METNASE AND INTNASE INHIBITORS AND THEIR USE IN TREATING CANCER | RNASE1, DCLRE1B, FEN1 | CCR8 3925/4885KMT2A 566/4885LMNA 1247/4885 |
| US-10457643-B2 | (−)-huperzine A processes and related compositions and methods of treatment | CHRNA5, HTR2A, GRIK5 | CCR8 4467/4885KMT2A 619/4885LMNA 404/4885 |
| US-20150158817-A1 | (--)-Huperzine A Processes and Related Compositions and Methods of Treatment | CHRNA5, HTR2A, HTT | CCR8 4590/4885KMT2A 443/4885LMNA 415/4885 |
| US-20200223860-A1 | THE TOTAL SYNTHESIS OF GLUCOSEPANE AND RELATED CHEMICAL REACTIONS, COMPOUNDS AND COMPOSITIONS AND OBTAINED THEREFROM AND METHODS OF TREATMENT | PTMS, AGER, GALE | CCR8 4795/4885KMT2A 1532/4885LMNA 2064/4885 |
| US-12134602-B2 | (−)-huperzine A processes and related compositions and methods of treatment | CHRNA5, HTR2A, GRIK5 | CCR8 4467/4885KMT2A 619/4885LMNA 404/4885 |
| US-20200109118-A1 | (--)-HUPERZINE A PROCESSES AND RELATED COMPOSITIONS AND METHODS OF TREATMENT | CHRNA5, HTR2A, HTT | CCR8 4590/4885KMT2A 443/4885LMNA 415/4885 |
| US-20220064123-A1 | (--)-Huperzine A Processes and Related Compositions and Methods of Treatment | CHRNA5, HTR2A, HTT | CCR8 4590/4885KMT2A 443/4885LMNA 415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.