Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.31 |
| ▸ | CTSS | P25774 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
| ▸ | BRD1 | O95696 | 2/20 | 0.31 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.31 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.31 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.31 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.30 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20907575 | 1.00 | MMP1 (0.34) | MMP1ADAM17ALOX5OPRK1CTSS | |
| SCHEMBL20908216 | 0.92 | MMP1 (0.36) | MMP1ADAM17ALOX5CTSSSMN1; SMN2 | |
| SCHEMBL29640227 | 0.92 | MMP1 (0.36) | MMP1ADAM17ALOX5CTSSSMN1; SMN2 | |
| SCHEMBL21112302 | 0.82 | MEN1 (0.39) | MMP1ADAM17ALOX5CTSSSMN1; SMN2 | |
| SCHEMBL21112298 | 0.82 | MEN1 (0.39) | MMP1ADAM17ALOX5CTSSSMN1; SMN2 | |
| SCHEMBL29640353 | 0.81 | OPRK1 (0.39) | OPRK1CTSSSMN1; SMN2MEN1KMT2A | |
| SCHEMBL28407518 | 0.81 | AAK1 (0.40) | OPRK1CTSSSMN1; SMN2MEN1KMT2A | |
| SCHEMBL22579540 | 0.81 | AAK1 (0.40) | OPRK1CTSSSMN1; SMN2MEN1KMT2A | |
| SCHEMBL23114827 | 0.81 | CTSS (0.33) | OPRK1CTSSSMN1; SMN2MEN1KMT2A | |
| SCHEMBL20908278 | 0.81 | CTSS (0.33) | OPRK1CTSSSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10774053-B2 | HIV protease inhibitors | GILEAD SCIENCES, INC. (US) | 2020-09-15 | — | — | US | disclosed |
| US-20190210978-A1 | HIV PROTEASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2019-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10774053-B2 | HIV protease inhibitors | PRSS1, SERPINB1, FURIN | MMP1 87/4885ADAM17 12/4885ALOX5 3256/4885 |
| US-20190210978-A1 | HIV PROTEASE INHIBITORS | PRSS1, SERPINB1, HPN | MMP1 135/4885ADAM17 7/4885ALOX5 3149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.