Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.38 |
| ▸ | PTPRB | P23467 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21150835 | 0.88 | NR1H2 (0.39) | TSHRALOX15ATMGPR119MEN1 | |
| SCHEMBL21150851 | 0.85 | GPR119 (0.39) | TSHRALOX15ATMGPR119MEN1 | |
| SCHEMBL21152108 | 0.80 | POLB (0.34) | KDM4EPKMPTPRBPTPN11 | |
| SCHEMBL3489718 | 0.76 | TSHR (0.45) | TSHRALOX15ATMGPR119KDM4E | |
| SCHEMBL21152096 | 0.75 | OPRM1 (0.43) | KDM4EMEN1KMT2AOPRD1OPRK1 | |
| SCHEMBL17140845 | 0.74 | GPR119 (0.51) | TSHRALOX15ATMGPR119KDM4E | |
| SCHEMBL14346584 | 0.72 | ALDH1A1 (0.39) | TSHRALOX15GPR119STSNAMPT | |
| SCHEMBL17848498 | 0.72 | GPR119 (0.48) | TSHRALOX15ATMGPR119KDM4E | |
| SCHEMBL5726017 | 0.72 | TSHR (0.44) | TSHRALOX15ATMGPR119KDM4E | |
| SCHEMBL4443471 | 0.70 | USP2 (0.46) | TSHRALOX15ATMGPR119KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019136442-A1 | CD16A BINDING AGENTS AND USES THEREOF | KLEO PHARMACEUTICALS, INC. (US) | 2019-07-11 | — | — | WO | disclosed |