Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.30 |
| ▸ | FABP4 | P15090 | 2/20 | 0.30 |
| ▸ | FABP3 | P05413 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16481978 | 0.84 | IDO1 (0.45) | IDO1MGAMGAASIMGAM2 | |
| SCHEMBL3322110 | 0.75 | MGAM (0.47) | IDO1MGAMGAASIMGAM2 | |
| SCHEMBL21163207 | 0.73 | MEN1 (0.35) | GAASMN1; SMN2LMNAHPGDNPC1 | |
| SCHEMBL29565108 | 0.70 | KMO (0.38) | IDO1MGAMGAASIMGAM2 | |
| SCHEMBL17069012 | 0.69 | NUDT1 (0.36) | MGAMGAASIMGAM2SMN1; SMN2 | |
| SCHEMBL8973406 | 0.69 | L3MBTL1 (0.40) | ADORA2AADORA1SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL10792280 | 0.68 | SMN1; SMN2 (0.49) | ADORA2AADORA1IDO1SMN1; SMN2LMNA | |
| SCHEMBL4591602 | 0.67 | KDM4E (0.42) | ADORA2AADORA1MGAMGAASI | |
| Hydrochloric Acid SCHEMBL4345831 | 0.67 | HPGD (0.38) | MGAMGAASIMGAM2SMN1; SMN2 | |
| SCHEMBL24360032 | 0.66 | DCUN1D1 (0.50) | IDO1GAASMN1; SMN2HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906553-B1 | OREXIN RECEPTOR ANTAGONISTS WHICH ARE [ORTHO BI (HETERO )ARYL]-[2-(META BI (HETERO)ARYL)-PYRROLIDIN-1-YL]-METHANONE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2019-06-26 | — | — | EP | disclosed |