Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL822601 | 0.90 | MAPK1 (0.63) | MAPK1HIF1ATHRBTDP1SLC6A3 | |
| SCHEMBL10026131 | 0.87 | THRB (0.54) | MAPK1HIF1ATHRBALDH1A1SMN1; SMN2 | |
| SCHEMBL16314606 | 0.87 | THRB (0.54) | MAPK1HIF1ATHRBALDH1A1SMN1; SMN2 | |
| SCHEMBL27058521 | 0.85 | MAPK1 (0.47) | MAPK1HIF1ATHRBTDP1ALDH1A1 | |
| SCHEMBL890407 | 0.85 | MAPK1 (0.56) | MAPK1HIF1ATHRBTDP1SLC6A3 | |
| SCHEMBL20192056 | 0.85 | MAPK1 (0.56) | MAPK1HIF1ATHRBTDP1SLC6A3 | |
| SCHEMBL13477884 | 0.83 | THRB (0.57) | MAPK1HIF1ATHRBALDH1A1SMN1; SMN2 | |
| SCHEMBL16142139 | 0.83 | MAPK1 (0.54) | MAPK1HIF1ATHRBTDP1SLC6A3 | |
| SCHEMBL16314554 | 0.81 | ALDH1A1 (0.58) | MAPK1HIF1ATHRBALDH1A1SMN1; SMN2 | |
| SCHEMBL21318094 | 0.80 | ESR1 (0.51) | MAPK1HIF1ATHRBTDP1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190209690-A9 | Bioreducible Poly (Beta-Amino Ester)s For siRNA Delivery | THE JOHNS HOPKINS UNIVERSITY (US) | 2019-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190209690-A9 | Bioreducible Poly (Beta-Amino Ester)s For siRNA Delivery | AARS1, SLC43A1, PHAX | MAPK1 4050/4885HIF1A 691/4885THRB 1361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.