Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 4/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.33 |
| ▸ | CMA1 | P23946 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20032460 | 0.94 | RORC (0.36) | RORCBRD4PTGDR2PTGES2CMA1 | |
| SCHEMBL20032477 | 0.91 | BRD4 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL18713626 | 0.88 | PTGDR2 (0.40) | RORCBRD4PTGDR2PTGES2CMA1 | |
| SCHEMBL18713627 | 0.87 | PTGES2 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21164534 | 0.84 | BRD4 (0.44) | RORCBRD4PTGDR2PTGES2 | |
| SCHEMBL21366949 | 0.83 | ALDH1A1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL16573995 | 0.80 | PKM (0.39) | RORCBRD4PTGDR2PTGES2 | |
| SCHEMBL20032444 | 0.79 | RORC (0.41) | RORCPTGES2 | |
| SCHEMBL18713724 | 0.78 | CA1 (0.46) | BRD4PTGES2 | |
| SCHEMBL20032433 | 0.77 | PTGDR2 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10350208-B2 | Spirocyclic compounds as tryptophan hydroxylase inhibitors | ROIVANT SCIENCES GMBH (CH) | 2019-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10350208-B2 | Spirocyclic compounds as tryptophan hydroxylase inhibitors | TPH1, TPH2, HTR1A | PSEN1 2972/4885PSEN2 4255/4885APH1B 2805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.