Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GPR142 | Q7Z601 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.32 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.32 |
| ▸ | SOAT2 | O75908 | 2/20 | 0.32 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211943 | 0.94 | MAPT (0.41) | MAPTRAB9AGPR142POLBNTRK1 | |
| SCHEMBL210849 | 0.89 | TRPV4 (0.32) | GRM5 | |
| SCHEMBL2726206 | 0.87 | MAPT (0.40) | MAPTRAB9AGPR142POLBNTRK1 | |
| SCHEMBL212791 | 0.87 | MAPT (0.40) | MAPTRAB9A | |
| SCHEMBL213271 | 0.85 | SCD5 (0.34) | MAPTRAB9APOLBLMNA | |
| SCHEMBL211534 | 0.83 | CSNK2A2 (0.40) | RAB9A | |
| SCHEMBL212044 | 0.83 | GRM5 (0.31) | GRM5 | |
| SCHEMBL210463 | 0.82 | MAPT (0.41) | MAPTRAB9A | |
| SCHEMBL211855 | 0.81 | MAPK14 (0.31) | NTRK1 | |
| SCHEMBL211083 | 0.81 | CTSK (0.35) | RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |