Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.31 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL212044 | 0.94 | GRM5 (0.31) | CACNA1GCACNA1HGRM5 | |
| SCHEMBL211687 | 0.89 | MAPT (0.40) | GRM5 | |
| SCHEMBL2727738 | 0.87 | CACNA1G (0.34) | TRPV4CACNA1GCACNA1HGRM5 | |
| SCHEMBL213271 | 0.86 | SCD5 (0.34) | — | |
| SCHEMBL212791 | 0.83 | MAPT (0.40) | — | |
| SCHEMBL211083 | 0.83 | CTSK (0.35) | — | |
| SCHEMBL211133 | 0.83 | CTSK (0.35) | — | |
| SCHEMBL211943 | 0.83 | MAPT (0.41) | — | |
| SCHEMBL211534 | 0.82 | CSNK2A2 (0.40) | — | |
| SCHEMBL212349 | 0.82 | MAPT (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |