Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 5/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170152 | 0.95 | RIPK1 (0.41) | RIPK1HDAC6EPHX2ALOX5SOAT2 | |
| SCHEMBL21170174 | 0.90 | GPR52 (0.42) | RIPK1HDAC6ABL1EPHX2ALOX5 | |
| SCHEMBL21170095 | 0.87 | TP53BP1 (0.39) | RIPK1HDAC6BRD4TP53BP1 | |
| SCHEMBL21170091 | 0.86 | MAP4K4 (0.38) | RIPK1ABL1BCR | |
| SCHEMBL21170038 | 0.85 | DPP4 (0.42) | SOAT2SOAT1 | |
| SCHEMBL12287723 | 0.85 | DPP4 (0.42) | SOAT2SOAT1 | |
| SCHEMBL12287289 | 0.85 | DPP4 (0.42) | SOAT2SOAT1 | |
| SCHEMBL21170310 | 0.85 | ADORA1 (0.41) | RIPK1 | |
| SCHEMBL14990586 | 0.82 | HDAC6 (0.40) | HDAC6ABL1EGFRSRCSOAT2 | |
| SCHEMBL21170185 | 0.82 | TRPM8 (0.41) | SOAT2SOAT1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |