Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.39 |
| ▸ | SUCNR1 | Q9BXA5 | 4/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | ACACA | Q13085 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.37 |
| ▸ | UBE2M | P61081 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170046 | 0.87 | RIPK1 (0.40) | TP53BP1RIPK1HDAC6BRD4 | |
| SCHEMBL21170174 | 0.85 | GPR52 (0.42) | RIPK1HDAC6 | |
| SCHEMBL12289949 | 0.85 | UBE2M (0.39) | TP53BP1SUCNR1ACACBACACAUBE2M | |
| SCHEMBL21170152 | 0.85 | RIPK1 (0.41) | RIPK1HDAC6 | |
| SCHEMBL21170091 | 0.82 | MAP4K4 (0.38) | RIPK1 | |
| SCHEMBL21170310 | 0.81 | ADORA1 (0.41) | RIPK1GAA | |
| SCHEMBL21170039 | 0.79 | CRBN (0.44) | POLB | |
| SCHEMBL21170038 | 0.79 | DPP4 (0.42) | SCN9A | |
| SCHEMBL12287723 | 0.79 | DPP4 (0.42) | SCN9A | |
| SCHEMBL12287289 | 0.79 | DPP4 (0.42) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |