Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 2/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12287723 | 0.83 | DPP4 (0.42) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL12287289 | 0.83 | DPP4 (0.42) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL21170038 | 0.83 | DPP4 (0.42) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL21170185 | 0.82 | TRPM8 (0.41) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL21170091 | 0.82 | MAP4K4 (0.38) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL21170143 | 0.82 | GABRG2 (0.43) | NPY5RNPC1RAB9AMEN1KMT2A | |
| SCHEMBL21170174 | 0.81 | GPR52 (0.42) | FYNMAPK14 | |
| SCHEMBL21170310 | 0.80 | ADORA1 (0.41) | KMT2AALDH1A1 | |
| SCHEMBL21170220 | 0.79 | FAAH (0.43) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL12286561 | 0.78 | NPC1 (0.39) | NPY5RNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |