Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.31 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
| ▸ | IL1B | P01584 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170460 | 0.81 | AKT1 (0.39) | ADORA3ADORA2ATDO2RAB9AMAPK14 | |
| SCHEMBL2564274 | 0.80 | ADORA3 (0.34) | ADORA3ADORA2ATDO2RAB9AMAPK14 | |
| SCHEMBL21170335 | 0.78 | EP300 (0.45) | ADORA3ADORA2ATDO2RAB9AMAPK14 | |
| SCHEMBL21170458 | 0.75 | MAPK1 (0.43) | RAB9AMAPK1MAPK13MAPK12 | |
| SCHEMBL21170121 | 0.72 | NNMT (0.40) | — | |
| SCHEMBL21170314 | 0.72 | NPC1 (0.41) | ADORA3ADORA2ARAB9AMAPTADORA1 | |
| SCHEMBL21170220 | 0.71 | FAAH (0.43) | RAB9AMAPK14TP53MAPTTHRB | |
| SCHEMBL21170038 | 0.71 | DPP4 (0.42) | RAB9AMAPK14 | |
| SCHEMBL12287723 | 0.71 | DPP4 (0.42) | RAB9AMAPK14 | |
| SCHEMBL2380377 | 0.71 | ADORA3 (0.54) | ADORA3ADORA2ATDO2RAB9AMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |