Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 10/20 | 0.67 |
| ▸ | HTR6 | P50406 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 8/20 | 0.50 |
| ▸ | CA9 | Q16790 | 8/20 | 0.50 |
| ▸ | CA12 | O43570 | 4/20 | 0.50 |
| ▸ | CA4 | P22748 | 3/20 | 0.50 |
| ▸ | CA6 | P23280 | 3/20 | 0.50 |
| ▸ | CA5A | P35218 | 3/20 | 0.50 |
| ▸ | CA7 | P43166 | 2/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 3/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29469920 | 1.00 | CA2 (0.67) | CA2HTR6CA1CA9CA12 | |
| SCHEMBL10891110 | 0.82 | CA2 (0.51) | CA2HTR6CA1CA9CA12 | |
| SCHEMBL8149846 | 0.80 | CA2 (0.64) | CA2HTR6CA1CA9CA12 | |
| SCHEMBL108421 | 0.80 | CA2 (1.00) | CA2CA1CA9F2PRSS1 | |
| SCHEMBL28584350 | 0.80 | CA2 (0.54) | CA2HTR6CA1CA9CA12 | |
| SCHEMBL3971963 | 0.79 | HTR6 (0.56) | CA2HTR6CA1CA9CA12 | |
| SCHEMBL11407481 | 0.79 | CA2 (0.96) | CA2CA1CA9F2PRSS1 | |
| SCHEMBL7633146 | 0.79 | CA2 (0.49) | CA2HTR6CA1CA9CA12 | |
| SCHEMBL29581330 | 0.79 | CA2 (0.49) | CA2HTR6CA1CA9CA12 | |
| SCHEMBL6265807 | 0.78 | HTR6 (0.60) | CA2HTR6CA1CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2056829-A2 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | Exelixis, Inc. (US) | 2009-05-13 | — | — | EP | claimed |
| WO-2008021389-A2 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | EXELIXIS, INC. (US) | 2008-02-21 | — | — | WO | claimed |
| EP-0794952-B1 | POLYMERISABLE AROMATIC CARBOXYLIC ACID AND CARBOXYLIC ACID ANHYDRIDES WITH CYCLIC CARBONATE GROUPS AND COMPOSITIONS THAT CONTAIN THESE COMPOUNDS | HERAEUS KULZER GMBH & CO KG (DE) | 2000-02-23 | — | — | EP | claimed |
| EP-3765447-A1 | TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS | Kezar Life Sciences (US) | 2021-01-20 | — | — | EP | disclosed |
| WO-2019178510-A1 | TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-09-19 | — | — | WO | disclosed |
| US-20120095024-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE | ELARA PHARMACEUTICALS GMBH (DE) | 2012-04-19 | — | — | US | disclosed |
| US-20100204187-A1 | Purine Derivatives | PALAU PHARMA, S.A. (ES) | 2010-08-12 | — | — | US | disclosed |
| EP-2056829-A2 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | Exelixis, Inc. (US) | 2009-05-13 | — | — | EP | disclosed |
| US-20080286377-A1 | ANTI-RESORPTIVE BONE CEMENTS AND ALLOGENEIC, AUTOGRAFIC, AND XENOGRAFIC BONE GRAFTS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2008-11-20 | — | — | US | disclosed |
| WO-2008021389-A2 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | EXELIXIS, INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| EP-1444972-B1 | Hardenable dental material | HERAEUS KULZER GMBH (DE) | 2006-03-29 | — | — | EP | disclosed |
| EP-0776650-A2 | Dental adhesive | Heraeus Kulzer GmbH (DE) | 1997-06-04 | — | — | EP | disclosed |
| WO-1997003063-A1 | POLYMERISABLE AROMATIC CARBOXYLIC ACID AND CARBOXYLIC ACID ANHYDRIDES WITH CYCLIC CARBONATE GROUPS AND COMPOSITIONS THAT CONTAIN THESE COMPOUNDS | HERAEUS KULZER GMBH (DE) | 1997-01-30 | — | — | WO | disclosed |
| EP-0497157-B1 | Crosslinked molded dental articles | HERAEUS KULZER GMBH (DE) | 1996-10-16 | — | — | EP | disclosed |
| EP-0471252-B1 | N-alkyl-N-(meth)acryloyloxyalkylcarboxamides of aromatic carboxylic acids and of aromatic carboxylic anhydrides and adhesives containing these compounds | BAYER AG (DE) | 1994-03-30 | — | — | EP | disclosed |
| US-5294646-A | N-alkyl-n-(meth)acryloyloxyalkylcarboxamides of aromatic carboxylic acids and aromatic carboxylic acid anhydrides, and adhesives containing these compounds | BAYER AKTIENGESELLSCHAFT (DE) | 1994-03-15 | — | — | US | disclosed |
| US-5270350-A | Polyfunctional (meth)acrylic acid ester | BAYER AKTIENGESELLSCHAFT (DE) | 1993-12-14 | — | — | US | disclosed |
| US-5241081-A | N-ALKYL-N-(METH)ACRYLOYLOXYALKYLCARBOXAMIDES OF AROMATIC CARBOXYLIC ACIDS AND AROMATIC CARBOXYLIC ACID ANHYDRIDES, AND ADHESIVES CONTAINING THESE COMPOUNDS | BAYER AKTIENGESELLSCHAFT (DE) | 1993-08-31 | — | — | US | disclosed |
| EP-0497157-A2 | Crosslinked molded dental articles | Heraeus Kulzer GmbH & Co.KG (DE) | 1992-08-05 | — | — | EP | disclosed |
| EP-0471252-A1 | N-alkyl-N-(meth)acryloyloxyalkylcarboxamides of aromatic carboxylic acids and of aromatic carboxylic anhydrides and adhesives containing these compounds | BAYER AG (DE) | 1992-02-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204187-A1 | Purine Derivatives | JAK3, JAK1, JAK2 | CA2 4678/4885HTR6 1889/4885CA1 4720/4885 |
| US-20080286377-A1 | ANTI-RESORPTIVE BONE CEMENTS AND ALLOGENEIC, AUTOGRAFIC, AND XENOGRAFIC BONE GRAFTS | SOST, BMP6, BMP2 | CA2 2655/4885HTR6 3965/4885CA1 1814/4885 |
| US-20120095024-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE | HIF1AN, HIF1A, EGLN2 | CA2 291/4885HTR6 3946/4885CA1 1620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.