Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cercosporin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TCF4 | P15884 | 4/20 | 0.65 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.65 |
| ▸ | CDH1 | P12830 | 1/20 | 0.65 |
| ▸ | APC | P25054 | 1/20 | 0.65 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | P4HB | P07237 | 3/20 | 0.31 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | SMAD3 | P84022 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cercosporin SCHEMBL6305985 | 0.94 | TCF4 (0.71) | TCF4CTNNB1CDH1APCTCF7L2 | |
| Cercosporin SCHEMBL498747 | 0.94 | TCF4 (0.71) | TCF4CTNNB1CDH1APCTCF7L2 | |
| Cercosporin SCHEMBL29613349 | 0.94 | TCF4 (0.71) | TCF4CTNNB1CDH1APCTCF7L2 | |
| Cercosporin SCHEMBL15185706 | 0.94 | TCF4 (0.71) | TCF4CTNNB1CDH1APCTCF7L2 | |
| Cercosporin SCHEMBL28102616 | 0.93 | TCF4 (0.70) | TCF4CTNNB1CDH1APCTCF7L2 | |
| SCHEMBL22930428 | 0.88 | TCF4 (0.64) | TCF4CTNNB1CDH1APCTCF7L2 | |
| SCHEMBL29369377 | 0.79 | CTNNB1 (1.00) | TCF4CTNNB1CDH1APCTCF7L2 | |
| SCHEMBL13121634 | 0.77 | CTNNB1 (0.49) | TCF4CTNNB1CDH1APCTCF7L2 | |
| SCHEMBL8476647 | 0.68 | TCF4 (0.42) | TCF4CTNNB1CDH1APCTCF7L2 | |
| SCHEMBL29711267 | 0.62 | CTNNB1 (0.68) | TCF4CTNNB1CDH1APCTCF7L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11359044-B2 | Preparation and application of novel multifunctional nanocomposite material with new photosensitizer | JIANGNAN UNIVERSITY (CN) | 2022-06-14 | — | — | US | disclosed |
| CN-106267249-B | Application of radioisotope-labeled perylenequinones in preparation of necrotic myocardial imaging agent | 中国药科大学 | 2020-01-31 | — | — | CN | disclosed |
| US-20190224318-A1 | Preparation and Application of Novel Multifunctional Nanocomposite Material with new Photosensitizer | JIANGNAN UNIVERSITY (CN) | 2019-07-25 | — | — | US | disclosed |
| CN-108187068-B | A kind of preparation and its application of photosensitizer composite Nano multifunctional material | 江南大学 | 2019-04-23 | — | — | CN | disclosed |
| CN-108187068-A | A kind of preparation and its application of novel photosensitive agent composite Nano multifunctional material | 江南大学 | 2018-06-22 | — | — | CN | disclosed |
| CN-106267249-A | The application in preparing necrotic myocardium developer of the labelled with radioisotope quinones | 中国药科大学 | 2017-01-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190224318-A1 | Preparation and Application of Novel Multifunctional Nanocomposite Material with new Photosensitizer | GPI, GYPA, FUT6 | TCF4 4882/4885CTNNB1 3425/4885CDH1 2016/4885 |
| US-11359044-B2 | Preparation and application of novel multifunctional nanocomposite material with new photosensitizer | GPI, GYPA, FUT6 | TCF4 4882/4885CTNNB1 3425/4885CDH1 2016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.