Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TCF4 | P15884 | 2/20 | 0.64 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.64 |
| ▸ | CDH1 | P12830 | 1/20 | 0.64 |
| ▸ | APC | P25054 | 1/20 | 0.64 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cercosporin SCHEMBL6305985 | 0.94 | TCF4 (0.71) | TCF4CTNNB1CDH1APCTCF7L2 | |
| Cercosporin SCHEMBL498747 | 0.94 | TCF4 (0.71) | TCF4CTNNB1CDH1APCTCF7L2 | |
| Cercosporin SCHEMBL15185706 | 0.94 | TCF4 (0.71) | TCF4CTNNB1CDH1APCTCF7L2 | |
| Cercosporin SCHEMBL29613349 | 0.94 | TCF4 (0.71) | TCF4CTNNB1CDH1APCTCF7L2 | |
| Cercosporin SCHEMBL28102616 | 0.92 | TCF4 (0.70) | TCF4CTNNB1CDH1APCTCF7L2 | |
| Cercosporin SCHEMBL21175561 | 0.88 | TCF4 (0.65) | TCF4CTNNB1CDH1APCTCF7L2 | |
| SCHEMBL29369377 | 0.78 | CTNNB1 (1.00) | TCF4CTNNB1CDH1APCTCF7L2 | |
| SCHEMBL13121634 | 0.76 | CTNNB1 (0.49) | TCF4CTNNB1CDH1APCTCF7L2 | |
| SCHEMBL8476647 | 0.67 | TCF4 (0.42) | TCF4CTNNB1CDH1APCTCF7L2 | |
| SCHEMBL29711267 | 0.62 | CTNNB1 (0.68) | TCF4CTNNB1CDH1APCTCF7L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230014124-A1 | HETEROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION | C4 THERAPEUTICS, INC. (US) | 2023-01-19 | — | — | US | disclosed |
| US-11185592-B2 | Spirocyclic degronimers for target protein degradation | C4 THERAPEUTICS, INC. (US) | 2021-11-30 | — | — | US | disclosed |
| US-20210106688-A1 | SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION | C4 THERAPEUTICS, INC. (US) | 2021-04-15 | — | — | US | disclosed |
| US-10905768-B1 | Heterocyclic degronimers for target protein degradation | C4 THERAPEUTICS, INC. (US) | 2021-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230014124-A1 | HETEROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION | CRBN, MDM2, STUB1 | TCF4 1074/4885CTNNB1 920/4885CDH1 1460/4885 |
| US-11185592-B2 | Spirocyclic degronimers for target protein degradation | STUB1, UBE3C, UBE3A | TCF4 2132/4885CTNNB1 1267/4885CDH1 1463/4885 |
| US-20210106688-A1 | SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION | STUB1, UBE3C, UBE3A | TCF4 2132/4885CTNNB1 1267/4885CDH1 1463/4885 |
| US-10905768-B1 | Heterocyclic degronimers for target protein degradation | CRBN, MDM2, STUB1 | TCF4 1074/4885CTNNB1 920/4885CDH1 1460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.