Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6270454 | 0.72 | FAAH (0.59) | FAAHCNR2DRD3DRD2HSD17B10 | |
| SCHEMBL30040362 | 0.71 | OPRK1 (0.46) | CNR2HSD17B10KMT2AOPRK1 | |
| SCHEMBL22820372 | 0.71 | OPRK1 (0.46) | CNR2HSD17B10KMT2AOPRK1 | |
| SCHEMBL23243125 | 0.68 | WDR5 (0.45) | KDM4EMEN1MAPTKMT2AOPRK1 | |
| SCHEMBL24683590 | 0.68 | OPRK1 (0.46) | KDM4EHSD17B10OPRK1 | |
| SCHEMBL22820451 | 0.66 | MAOA (0.42) | CNR2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL24252867 | 0.66 | APLNR (0.34) | MEN1MAPTKMT2AMAPK1ADAM17 | |
| SCHEMBL18512332 | 0.66 | HSD17B10 (0.41) | FAAHCNR2KDM4EHSD17B10PKM | |
| SCHEMBL19657313 | 0.65 | CREBBP (0.49) | KAT2BBAZ2BCNR2MAPK1BRD4 | |
| SCHEMBL30810295 | 0.65 | KDM4E (0.38) | DRD2GCKKDM4EHSD17B10OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3740489-A1 | PI4KIIIBETA INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2020-11-25 | — | — | EP | disclosed |
| WO-2019141694-A1 | PI4KIIIBETA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-07-25 | — | — | WO | disclosed |