Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GHSR | Q92847 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2118702 | 0.88 | MAPT (0.49) | SMN1; SMN2ALDH1A1TDP1MAPTHSD11B1 | |
| SCHEMBL2118455 | 0.88 | HSD11B1 (0.60) | SMN1; SMN2ALDH1A1MAPTHSD11B1TP53 | |
| SCHEMBL2120601 | 0.83 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1TDP1MAPTCYP2C9 | |
| SCHEMBL2119919 | 0.80 | MCL1 (0.57) | SMN1; SMN2ALDH1A1TDP1CYP3A4MAPT | |
| SCHEMBL2118236 | 0.78 | CYP2C9 (0.54) | SMN1; SMN2ALDH1A1TDP1CYP3A4MAPT | |
| SCHEMBL2118451 | 0.78 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1TDP1CYP3A4MAPT | |
| SCHEMBL2119905 | 0.78 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1TDP1CYP3A4MAPT | |
| SCHEMBL2122571 | 0.77 | PIK3CD (0.51) | SMN1; SMN2MAPTTP53POLBKMT2A | |
| SCHEMBL2118244 | 0.76 | ABCB1 (0.51) | SMN1; SMN2TDP1POLBGHSRMEN1 | |
| SCHEMBL2117625 | 0.76 | HSD17B1 (0.48) | SMN1; SMN2ALDH1A1TDP1CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095024-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE | ELARA PHARMACEUTICALS GMBH (DE) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095024-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE | HIF1AN, HIF1A, EGLN2 | SMN1; SMN2 3684/4885ALDH1A1 567/4885TDP1 1828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.