SCHEMBL21183649

SCHEMBL21183649

O=C1c2ccccc2SCc2c(F)cccc21

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MIF P14174 1/20 0.42
MAOB P27338 1/20 0.42
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
ALOX15 P16050 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
ALDH1A1 P00352 1/20 0.38
AKR1B1 P15121 1/20 0.36
PTGS2 P35354 2/20 0.36
PTGS1 P23219 1/20 0.36
TP53 P04637 1/20 0.36
CDC25B P30305 1/20 0.35
TYR P14679 1/20 0.35
PIM1 P11309 1/20 0.35
S100A4 P26447 1/20 0.35
SRD5A1 P18405 1/20 0.35
ACHE P22303 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20924695 0.84 MAOB (0.43) MIFMAOBMEN1KMT2AALOX15
SCHEMBL12998131 0.80 MIF (0.42) MIFMAOBMEN1KMT2AALOX15
SCHEMBL2601487 0.80 MIF (0.42) MIFMAOBMEN1KMT2AALOX15
SCHEMBL22261555 0.80 MIF (0.42) MIFMAOBMEN1KMT2AALOX15
SCHEMBL18796296 0.80 MAOB (0.49) MIFMAOBMEN1KMT2AALOX15
SCHEMBL10446873 0.80 MIF (0.42) MIFMAOBMEN1KMT2AALOX15
SCHEMBL10446552 0.78 MIF (0.43) MIFMAOBMEN1KMT2AALOX15
SCHEMBL15143562 0.78 ACHE (0.43) MIFMAOBALDH1A1AKR1B1TP53
SCHEMBL2601430 0.78 PIM1 (0.44) MIFMAOBMEN1KMT2AALOX15
SCHEMBL2601428 0.76 ALDH1A1 (0.49) MIFMAOBMEN1KMT2AALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10596171-B2 Cap-dependent endonuclease inhibitors TAIGEN BIOTECHNOLOGY CO., LTD. (TW) 2020-03-24 US disclosed
WO-2019144089-A1 CAP-DEPENDENT ENDONUCLEASE INHIBITORS TAIGEN BIOTECHNOLOGY CO., LTD. (TW) 2019-07-25 WO disclosed
US-20190224198-A1 CAP-DEPENDENT ENDONUCLEASE INHIBITORS TAIGEN BIOTECHNOLOGY CO., LTD. (TW) 2019-07-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190224198-A1 CAP-DEPENDENT ENDONUCLEASE INHIBITORS RNGTT, RNASEH1, RNASEL MIF 2881/4885MAOB 317/4885MEN1 3256/4885
US-10596171-B2 Cap-dependent endonuclease inhibitors RNGTT, RNASEH1, RNASEL MIF 2881/4885MAOB 317/4885MEN1 3256/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.