Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.68 |
| ▸ | USP2 | O75604 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 4/20 | 0.67 |
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 5/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18479753 | 0.84 | LMNA (0.69) | ALDH1A1RXFP1USP2TSHRGAA | |
| SCHEMBL16076163 | 0.83 | LMNA (0.64) | ALDH1A1RXFP1USP2TSHRGAA | |
| SCHEMBL17626296 | 0.81 | LMNA (0.62) | ALDH1A1RXFP1USP2TSHRGAA | |
| SCHEMBL18441008 | 0.81 | ALDH1A1 (0.62) | ALDH1A1RXFP1USP2TSHRGAA | |
| SCHEMBL18479752 | 0.81 | ALDH1A1 (0.66) | ALDH1A1RXFP1USP2TSHRGAA | |
| SCHEMBL9331481 | 0.81 | ALDH1A1 (1.00) | ALDH1A1RXFP1USP2TSHRGAA | |
| SCHEMBL16027916 | 0.81 | LMNA (0.58) | ALDH1A1RXFP1USP2TSHRGAA | |
| SCHEMBL2501268 | 0.80 | RXFP1 (0.59) | ALDH1A1RXFP1USP2TSHRGAA | |
| SCHEMBL25239535 | 0.80 | TSHR (0.67) | ALDH1A1RXFP1USP2TSHRL3MBTL1 | |
| SCHEMBL460340 | 0.80 | CYP1A2 (0.75) | USP2TSHRL3MBTL1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100280039-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING CHLOROPHENYL PIPERAZINE DERIVED COMPOUNDS AND USE OF THE COMPOUNDS IN PRODUCING MEDICAMENTS | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2010-11-04 | — | — | US | claimed |
| EP-2999699-B1 | PURINE DIONES AS WNT PATHWAY MODULATORS | AGENCY SCIENCE TECH & RES (SG) | 2020-04-29 | — | — | EP | disclosed |
| US-20120094985-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING CHLOROPHENYL PIPERAZINE DERIVED COMPOUNDS AND USE OF THE COMPOUNDS IN PRODUCING MEDICAMENTS | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2012-04-19 | — | — | US | disclosed |
| US-20100280040-A1 | SYNTHESIS AND PHARMACOKINETIC ACTIVITIES OF PULMODIL AND PULMODIL-1, TWO CHLOROPHENYLPIPERAZINE SALT DERIVATIVES | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2010-11-04 | — | — | US | disclosed |
| US-20100280039-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING CHLOROPHENYL PIPERAZINE DERIVED COMPOUNDS AND USE OF THE COMPOUNDS IN PRODUCING MEDICAMENTS | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2010-11-04 | — | — | US | disclosed |
| US-20100280041-A1 | RHOKINASE-DEPENDENT INHIBITION ACTIVITY ON PULMONARY ARTERY ENDOTHELIUM DYSFUNCTION, MEDIAL WALL THICKNESS AND VASCULAR OBSTRUCTION OF PULMODIL AND PULMODIL-1 | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2010-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280040-A1 | SYNTHESIS AND PHARMACOKINETIC ACTIVITIES OF PULMODIL AND PULMODIL-1, TWO CHLOROPHENYLPIPERAZINE SALT DERIVATIVES | MCOLN1, AGTR1, CHRM1 | ALDH1A1 1756/4885RXFP1 1853/4885USP2 3094/4885 |
| US-20120094985-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING CHLOROPHENYL PIPERAZINE DERIVED COMPOUNDS AND USE OF THE COMPOUNDS IN PRODUCING MEDICAMENTS | HTR5A, TPH1, HTR2C | ALDH1A1 1448/4885RXFP1 3417/4885USP2 3596/4885 |
| US-20100280039-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING CHLOROPHENYL PIPERAZINE DERIVED COMPOUNDS AND USE OF THE COMPOUNDS IN PRODUCING MEDICAMENTS | HTR5A, TPH1, HTR2C | ALDH1A1 1448/4885RXFP1 3417/4885USP2 3596/4885 |
| US-20100280041-A1 | RHOKINASE-DEPENDENT INHIBITION ACTIVITY ON PULMONARY ARTERY ENDOTHELIUM DYSFUNCTION, MEDIAL WALL THICKNESS AND VASCULAR OBSTRUCTION OF PULMODIL AND PULMODIL-1 | ROCK1, MYLK, PTGIR | ALDH1A1 4001/4885RXFP1 342/4885USP2 3557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.