Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | MC3R | P41968 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ASPH | Q12797 | 1/20 | 0.33 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29936207 | 1.00 | ADORA3 (0.41) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL630383 | 0.83 | KDM4E (0.44) | TSHRHTTHSD17B10KMT2ATLR7 | |
| SCHEMBL30779709 | 0.83 | KDM4E (0.44) | TSHRHTTHSD17B10KMT2ATLR7 | |
| SCHEMBL4570471 | 0.81 | HTT (0.38) | TSHRHTTHSD17B10TLR7L3MBTL1 | |
| Hydrochloric Acid SCHEMBL629621 | 0.81 | KDM4E (0.42) | TSHRHTTHSD17B10KMT2ATLR7 | |
| SCHEMBL4570470 | 0.79 | GLA (0.38) | TSHRHTTHSD17B10KMT2ATLR7 | |
| SCHEMBL13990459 | 0.79 | LMNA (0.42) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL30801476 | 0.79 | HTT (0.37) | TSHRHTTHSD17B10TLR7L3MBTL1 | |
| SCHEMBL629620 | 0.79 | HTT (0.37) | TSHRHTTHSD17B10TLR7L3MBTL1 | |
| SCHEMBL21147721 | 0.79 | P2RX7 (0.42) | ADORA3HTTHSD17B10TLR7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2024-05-29 | — | — | EP | claimed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | claimed |
| US-12630533-B2 | Heterocyclic compounds useful as KCNT1 inhibitors | ACTIO BIOSCIENCES, INC. (US) | 2026-05-19 | — | — | US | disclosed |
| US-20250313548-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS KCNT1 INHIBITORS | ACTIO BIOSCIENCES, INC. | 2025-10-09 | — | — | US | disclosed |
| EP-4373817-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2024-05-29 | — | — | EP | disclosed |
| EP-3684184-B1 | HERBICIDALLY ACTIVE PYRIDYL-/PYRIMIDYL-PYRAZINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2023-06-21 | — | — | EP | disclosed |
| EP-3684184-B1 | HERBICIDALLY ACTIVE PYRIDYL-/PYRIMIDYL-PYRAZINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2023-06-21 | — | — | EP | disclosed |
| EP-4192582-A1 | KINASE INHIBITORS AND USES THEREOF | ABM Therapeutics Corporation (US) | 2023-06-14 | — | — | EP | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |
| CN-111372456-B | Herbicidally active pyridyl-/pyrimidinyl-pyrazine derivatives | 先正达参股股份有限公司 | 2022-10-18 | — | — | CN | disclosed |
| CN-113200985-B | Pteridinone compound and preparation method and application thereof | 南开大学 | 2022-09-09 | — | — | CN | disclosed |
| CN-101405258-B | N-2-(hetero)arylethylcarboxamide derivative, and pest-controlling agent comprising the same | NIHON NOHYAKU CO LTD | 2013-07-24 | — | — | CN | disclosed |
| EP-2271632-B1 | 3-TRIFLUOROMETHYL-PYRAZINE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS | HOFFMANN LA ROCHE (CH) | 2013-04-17 | — | — | EP | disclosed |
| US-8088920-B2 | 3-trifluoromethyl-pyrazine-2-carboxylic acid amide derivatives as HDL-cholesterol raising agents | HOFFMANN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-8088920-B2 | 3-trifluoromethyl-pyrazine-2-carboxylic acid amide derivatives as HDL-cholesterol raising agents | HOFFMANN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | disclosed |
| CN-101981015-A | 3-trifluoromethyl-pyrazine-2-carboxylic acid amide derivatives as HDL-cholesterol raising agents | HOFFMANN LA ROCHE | 2011-02-23 | — | — | CN | disclosed |
| CN-1956970-B | Substituted pyrazinecarboxylic acid anilide derivative or salt thereof, intermediate thereof, agricultural/horticultural agent and use thereof | NIHON NOHYAKU CO LTD | 2010-12-08 | — | — | CN | disclosed |
| US-20090247550-A1 | 3-TRIFLUOROMETHYL-PYRAZINE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-10-01 | — | — | US | disclosed |
| CN-101405258-A | N-2-(hetero)arylethylcarboxamide derivative, and pest-controlling agent comprising the same | NIHON NOHYAKU CO LTD (JP) | 2009-04-08 | — | — | CN | disclosed |
| CN-1956970-A | Substituted pyrazinecarboxylic acid anilide derivative or salt thereof, intermediate thereof, agricultural/horticultural agent and use thereof | NIHON NOHYAKU CO LTD (JP) | 2007-05-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247550-A1 | 3-TRIFLUOROMETHYL-PYRAZINE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS | CETP, APOB, PON1 | ADORA3 419/4885TSHR 220/4885MC4R 627/4885 |
| US-20250313548-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS KCNT1 INHIBITORS | KCNT1, KCNT2, KCNN3 | ADORA3 1717/4885TSHR 2956/4885MC4R 2549/4885 |
| US-12630533-B2 | Heterocyclic compounds useful as KCNT1 inhibitors | KCNT1, KCNT2, KCNJ2 | ADORA3 1356/4885TSHR 1125/4885MC4R 3171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.