SCHEMBL2122001

SCHEMBL2122001

COC(=O)C(C(=O)/C=C/c1ccc(O)c(OC)c1)C(=O)/C=C/c1ccc(O)c(OC)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 4/20 1.00
MMP9 P14780 4/20 1.00
MMP13 P45452 4/20 1.00
MMP8 P22894 2/20 1.00
APP P05067 4/20 0.68
CYP2D6 P10635 3/20 0.68
MAOB P27338 3/20 0.68
MAPT P10636 3/20 0.68
BACE1 P56817 3/20 0.68
CYP2C9 P11712 2/20 0.68
TSHR P16473 2/20 0.68
HSD17B10 Q99714 2/20 0.68
CYP1A2 P05177 2/20 0.68
ALOX5 P09917 2/20 0.68
NFKB1 P19838 2/20 0.68
HSD11B1 P28845 2/20 0.68
STAT3 P40763 2/20 0.68
NFKB2 Q00653 2/20 0.68
RELA Q04206 2/20 0.68
NFE2L2 Q16236 2/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30540958 1.00 MMP2 (1.00) MMP2MMP9MMP13MMP8APP
SCHEMBL16558601 0.91 MMP2 (0.82) MMP2MMP9MMP13MMP8APP
SCHEMBL29402680 0.87 MMP2 (0.78) MMP2MMP9MMP13MMP8APP
SCHEMBL19960594 0.86 MMP2 (0.76) MMP2MMP9MMP13MMP8APP
SCHEMBL2125194 0.84 MMP2 (0.72) MMP2MMP9MMP13MMP8APP
SCHEMBL5598941 0.84 APP (0.73) MMP2MMP9MMP13MMP8APP
SCHEMBL12088589 0.84 MMP9 (0.72) MMP2MMP9MMP13MMP8APP
SCHEMBL5598945 0.84 APP (0.73) MMP2MMP9MMP13MMP8APP
SCHEMBL10084352 0.84 MMP9 (0.72) MMP2MMP9MMP13MMP8APP
SCHEMBL30504665 0.83 MMP9 (0.71) MMP2MMP9MMP13MMP8APP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240360068-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2024-10-31 US disclosed
US-20230265041-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND TEHIR USES THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2023-08-24 US disclosed
US-20230265041-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND TEHIR USES THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2023-08-24 US disclosed
US-11608309-B2 Curcumin analogues as zinc chelators and their uses THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2023-03-21 US disclosed
US-20210053905-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2021-02-25 US disclosed
US-20210053905-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2021-02-25 US disclosed
US-10669227-B2 Curcumin analogues as zinc chelators and their uses THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 2020-06-02 US disclosed
US-10669227-B2 Curcumin analogues as zinc chelators and their uses THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 2020-06-02 US disclosed
US-20190254945-A1 INHIBITION OF MELANOGENESIS BY CHEMICALLY MODIFIED CURCUMINS THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2019-08-22 US disclosed
EP-3206488-B1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES UNIV NEW YORK STATE RES FOUND (US) 2019-08-21 EP disclosed
US-20160031795-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 2016-02-04 US disclosed
US-9220695-B2 Polyenolic zinc-binding agents (pezbins) actively promote inactivation of cancer stem cells and potentiate cytotoxic anti-tumor drug substances THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2015-12-29 US disclosed
US-9187406-B2 Curcumin analogues as zinc chelators and their uses THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 2015-11-17 US disclosed
US-9187406-B2 Curcumin analogues as zinc chelators and their uses THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 2015-11-17 US disclosed
US-20150150834-A1 POLYENOLIC ZINC-BINDING AGENTS (PEZBINS) ACTIVELY PROMOTE INACTIVATION OF CANCER STEM CELLS AND POTENTIATE CYTOTOXIC ANTI-TUMOR DRUG SUBSTANCES CHEM-MASTER INTERNATIONAL, INC. (US) 2015-06-04 US disclosed
US-20150073021-A1 CHEMICALLY MODIFIED CURCUMINS AS INHIBITORS OF ANTHRAX LETHAL FACTOR THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2015-03-12 US disclosed
US-20120095051-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES CHEM-MASTER INTERNATIONAL, INC. 2012-04-19 US disclosed
US-20120095051-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES CHEM-MASTER INTERNATIONAL, INC. 2012-04-19 US disclosed
WO-2010132815-A9 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 2011-01-13 WO disclosed
WO-2010132815-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 2010-11-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150073021-A1 CHEMICALLY MODIFIED CURCUMINS AS INHIBITORS OF ANTHRAX LETHAL FACTOR ANTXR2, APAF1, LITAF MMP2 224/4885MMP9 1104/4885MMP13 928/4885
US-20230265041-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND TEHIR USES NFRKB, NFKBIA, NFKB1 MMP2 32/4885MMP9 17/4885MMP13 12/4885
US-20120095051-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES NFKBIA, NFKB1, NFKB2 MMP2 19/4885MMP9 12/4885MMP13 11/4885
US-10669227-B2 Curcumin analogues as zinc chelators and their uses NFKBIA, NFKB1, NFKB2 MMP2 19/4885MMP9 12/4885MMP13 11/4885
US-20150150834-A1 POLYENOLIC ZINC-BINDING AGENTS (PEZBINS) ACTIVELY PROMOTE INACTIVATION OF CANCER STEM CELLS AND POTENTIATE CYTOTOXIC ANTI-TUMOR DRUG SUBSTANCES BAZ2B, CEBPZ, BAZ2A MMP2 2518/4885MMP9 1634/4885MMP13 886/4885
US-11608309-B2 Curcumin analogues as zinc chelators and their uses NFKBIA, NFKB1, NFKB2 MMP2 19/4885MMP9 12/4885MMP13 11/4885
US-20210053905-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES NFKBIA, NFKB1, NFKB2 MMP2 19/4885MMP9 12/4885MMP13 11/4885
US-20190254945-A1 INHIBITION OF MELANOGENESIS BY CHEMICALLY MODIFIED CURCUMINS TYR, MC1R, MITF MMP2 1633/4885MMP9 1649/4885MMP13 628/4885
US-20160031795-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES NFKBIA, NFKB1, NFKB2 MMP2 19/4885MMP9 12/4885MMP13 11/4885
US-20240360068-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES NFKBIA, NFKB1, NFKB2 MMP2 19/4885MMP9 12/4885MMP13 11/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.