SCHEMBL21225293

SCHEMBL21225293

NC(=O)CCC(NC(=O)O)C(=O)N1CC2(CCCCC2)CC1=O

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCKBR P32239 16/20 0.35
P2RY12 Q9H244 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21225289 1.00 CCKBR (0.35) CCKBRP2RY12
SCHEMBL21246539 0.84 ITGB3 (0.38)
Hydrochloric Acid SCHEMBL21224547 0.81 ALOX15 (0.35)
Hydrochloric Acid SCHEMBL21224546 0.81 ALOX15 (0.35)
SCHEMBL21225630 0.76 ITGB3 (0.40) CCKBR
SCHEMBL21225628 0.76 ITGB3 (0.40) CCKBR
SCHEMBL21246350 0.71 USP19 (0.34)
SCHEMBL21224580 0.70 LMNA (0.35)
SCHEMBL21246357 0.70 LMNA (0.35)
SCHEMBL21225110 0.68 GRM5 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019152688-A1 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF APTINYX INC. (US) 2019-08-08 WO disclosed