Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | PREP | P48147 | 3/20 | 0.36 |
| ▸ | CELA1 | Q9UNI1 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TOP1 | P11387 | 2/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | CFD | P00746 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23621178 | 0.76 | MEN1 (0.48) | CA2PREPKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL6936490 | 0.76 | PREP (0.46) | CA2PREPCELA1KDM4EHSD17B10 | |
| SCHEMBL9646427 | 0.76 | KDM4E (0.48) | CA2PREPCELA1KDM4EHSD17B10 | |
| SCHEMBL4647729 | 0.76 | HSD17B10 (0.50) | CA2PREPCELA1KDM4EHSD17B10 | |
| SCHEMBL1452119 | 0.76 | TOP1 (0.44) | PREPCELA1KDM4EHSD17B10MAPK1 | |
| SCHEMBL6544693 | 0.76 | KDM4E (0.44) | PREPCELA1KDM4EHSD17B10MAPK1 | |
| SCHEMBL14430071 | 0.74 | KDM4E (0.44) | CA2PREPCELA1KDM4EHSD17B10 | |
| SCHEMBL7827341 | 0.74 | PREP (0.48) | CA2PREPCELA1KDM4EHSD17B10 | |
| SCHEMBL13864993 | 0.74 | BACE1 (0.50) | CA2PREPKDM4EHSD17B10LMNA | |
| SCHEMBL7140477 | 0.72 | TUBB4A (0.46) | MAPK1ALDH1A1BACE1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210353631-A1 | 1,4-Benzoxazines for the Treatment of Cancers and Other Neurodegenerative Diseases | Neugeneron LLC | 2021-11-18 | — | — | US | claimed |
| US-20120094991-A1 | 1, 4-Benzoxazine Compounds and Derivatives Thereof as Therapeutic Drugs for the Treatment of Neurodegenerative Conditions | Southerm Methodist University (US) | 2012-04-19 | — | — | US | claimed |
| US-20210353631-A1 | 1,4-Benzoxazines for the Treatment of Cancers and Other Neurodegenerative Diseases | Neugeneron LLC | 2021-11-18 | — | — | US | disclosed |
| US-8680094-B2 | 1, 4-benzoxazine compounds and derivatives thereof as therapeutic drugs for the treatment of neurodegenerative conditions | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-03-25 | — | — | US | disclosed |
| US-20120094991-A1 | 1, 4-Benzoxazine Compounds and Derivatives Thereof as Therapeutic Drugs for the Treatment of Neurodegenerative Conditions | Southerm Methodist University (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210353631-A1 | 1,4-Benzoxazines for the Treatment of Cancers and Other Neurodegenerative Diseases | GBA1, NFXL1, CYP4X1 | CA2 3016/4885PREP 1957/4885CELA1 1012/4885 |
| US-20120094991-A1 | 1, 4-Benzoxazine Compounds and Derivatives Thereof as Therapeutic Drugs for the Treatment of Neurodegenerative Conditions | HYPK, HTT, HIPK4 | CA2 3094/4885PREP 2589/4885CELA1 1971/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.