Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.57 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5580077 | 0.92 | LTA4H (0.57) | LTA4HTRPA1ALDH1A1TP53CYP3A4 | |
| SCHEMBL1930129 | 0.90 | ALDH1A1 (0.61) | LTA4HTRPA1ALDH1A1TP53CYP3A4 | |
| SCHEMBL8710305 | 0.90 | TRPA1 (0.50) | LTA4HTRPA1ALDH1A1TP53CYP3A4 | |
| SCHEMBL7411959 | 0.85 | TRPA1 (0.53) | LTA4HTRPA1ALDH1A1TP53CYP3A4 | |
| SCHEMBL651317 | 0.84 | NPC1 (0.59) | ALDH1A1TP53CYP3A4ALOX15TSHR | |
| SCHEMBL3168388 | 0.83 | RELA (0.60) | ALDH1A1TP53CYP3A4ALOX15TSHR | |
| SCHEMBL7777160 | 0.83 | RELA (0.60) | ALDH1A1TP53CYP3A4ALOX15TSHR | |
| SCHEMBL15105021 | 0.81 | TRPA1 (0.63) | LTA4HTRPA1ALDH1A1TP53CYP3A4 | |
| SCHEMBL5507847 | 0.81 | ALDH1A1 (0.52) | ALDH1A1TP53CYP3A4ALOX15TSHR | |
| SCHEMBL6680147 | 0.81 | ALDH1A1 (0.52) | ALDH1A1TP53CYP3A4ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115716808-A | 18F-labeled triazoles containing PSMA inhibitors | 康奈尔大学 | 2023-02-28 | — | — | CN | claimed |
| US-8513244-B2 | Neprilysin inhibitors | THERAVANCE, INC. (US) | 2013-08-20 | — | — | US | claimed |
| US-20120094977-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION | DENDREON CORPORATION (US) | 2012-04-19 | — | — | US | claimed |
| US-5969131-A | OR PRECURSORS; CHEMICAL INTERMEDIATES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1999-10-19 | — | — | US | claimed |
| EP-0265685-B1 | COMBINATION OF ACE INHIBITORS WITH CALCIUM ANTAGONISTS, AND THEIR USE IN MEDICINES | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-07-29 | — | — | EP | claimed |
| CN-112939980-A | 3, 4-dichloroisothiazole heterocyclic purine derivatives and preparation method and application thereof | 南开大学 | 2021-06-11 | — | — | CN | disclosed |
| WO-2018119117-A1 | METHODS OF PRODUCING CYCLIC DINUCLEOTIDES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-06-28 | — | — | WO | disclosed |
| CN-107429247-A | Methods of making polynucleotides using multivalent cation salt compositions | 美国杰龙生物医药公司 | 2017-12-01 | — | — | CN | disclosed |
| CN-106459134-A | Oligonucleotide composition and method for preparing same | 美国杰龙生物医药公司 | 2017-02-22 | — | — | CN | disclosed |
| WO-2006102594-A1 | NUCLEOSIDE PRODRUGS FOR TREATING VIRAL INFECTIONS | GENELABS TECHNOLOGIES, INC. (US) | 2006-09-28 | — | — | WO | disclosed |
| EP-1560577-A2 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING TAXANE DERIVATIVES | Bristol-Myers Squibb Company (US) | 2005-08-10 | — | — | EP | disclosed |
| EP-1558241-A2 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING TAXANE DERIVATIVES | Bristol-Myers Squibb Company (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004043390-A2 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING TAXANE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-05-27 | — | — | WO | disclosed |
| CN-1066456-C | Nucleosides and oligonucleotides having 2'-ether groups | NOVARTIS AG (CH) | 2001-05-30 | — | — | CN | disclosed |
| CN-1196731-A | Di-glycosylated 1, 2-diols as mimetics of sialyl-lewis X and sialyl-lewis A | NOVARTIS AG (CH) | 1998-10-21 | — | — | CN | disclosed |
| US-5580865-A | ELASTASE INHIBITORS; ANTIINFLAMMATORY AGENTS; DEGENERATIVE DISEASES; EMPHYSEMA, ADULT RESPIRATORY DISTRESS SYNDROME, RHEUMATIC FEVER, SPONDYLITIS, GOUT, LUPUS AND PSORIASIS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1996-12-03 | — | — | US | disclosed |
| CN-1115320-A | Nucleosides and oligonucleotides having 2'-ether groups | CIBA GEIGY AG (CH) | 1996-01-24 | — | — | CN | disclosed |
| US-5418230-A | Antiinflammatory | SHIONOGI & CO., LTD. (JP) | 1995-05-23 | — | — | US | disclosed |
| EP-0564835-A2 | 2,2-Disubstituted cephem sulphones | PHARMACIA S.p.A. (IT) | 1993-10-13 | — | — | EP | disclosed |
| EP-0180252-B1 | PROCESS OF PREPARING AZETIDINONE COMPOUNDS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1989-04-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094977-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION | TRPC4, TRPC3, TRPC1 | LTA4H 91/4885TRPA1 31/4885ALDH1A1 4742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.