Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16595486 | 0.95 | MAPT (0.47) | MAPTLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21636260 | 0.91 | MAPT (0.49) | MAPTLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL859597 | 0.84 | CES2 (0.60) | MAPTALDH1A1SRD5A2EPHX2MEN1 | |
| SCHEMBL11486382 | 0.83 | MAPT (0.48) | MAPTLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11489326 | 0.83 | MAPT (0.48) | MAPTLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL571045 | 0.81 | CA12 (0.63) | MAPTLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21636244 | 0.81 | MAPT (0.53) | MAPTLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL167161 | 0.81 | CES2 (0.60) | MAPTLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1686313 | 0.80 | MAPT (0.61) | MAPTLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5820370 | 0.80 | MAPT (0.46) | MAPTLMNANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105663123-A | Application of tebufenpyrad structure containing compound to preparation of Ebola virus infection resisting medicines | 中国科学院微生物研究所 | 2016-06-15 | — | — | CN | disclosed |
| US-9150723-B2 | Curable resin composition | THREE BOND FINE CHEMICAL CO., LTD. (JP) | 2015-10-06 | — | — | US | disclosed |
| US-20140329926-A1 | CURABLE RESIN COMPOSITION | THREE BOND FINE CHEMICAL CO., LTD (JP) | 2014-11-06 | — | — | US | disclosed |
| EP-2792694-A1 | CURABLE RESIN COMPOSITION | Three Bond Fine Chemical Co., Ltd. (JP) | 2014-10-22 | — | — | EP | disclosed |
| US-RE44613-E1 | N-substituted glycine derivatives: hydroxylase inhibitors | GLAXOSMITHKLINE LLC (US) | 2013-11-26 | — | — | US | disclosed |
| EP-2444391-B1 | BASE AND RADICAL GENERATOR, COMPOSITION USING SAME AND METHOD FOR CURING SAME | THREE BOND CO LTD (JP) | 2013-11-06 | — | — | EP | disclosed |
| EP-2444391-A1 | BASE AND RADICAL GENERATOR, COMPOSITION USING SAME AND METHOD FOR CURING SAME | THREE BOND CO., LTD. (JP) | 2012-04-25 | — | — | EP | disclosed |
| US-20120095124-A1 | BASE AND RADICAL GENERATOR, COMPOSITION USING SAME AND METHOD FOR CURING SAME | THREE BOND CO., LTD. (JP) | 2012-04-19 | — | — | US | disclosed |
| US-7608621-B2 | Such as n-{[2-[(4-bromo-2-fluorophenyl)methyl]-5-hydroxy-6-(1-methylethyl)-3-oxo-2,3-dihydro-4-pyridazinyl]carbonyl}glycine; anemia; increasing erythropoietin production | SMITHKLINE BEECHAM, CORP. (US) | 2009-10-27 | — | — | US | disclosed |
| US-20090075989-A1 | NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS | BAYER SCHERING PHARMA AG (DE) | 2009-03-19 | — | — | US | disclosed |
| US-4150148-A | NITROSUBSTITUTED | WILLIAM H. RORER, INC. (US) | 1979-04-17 | — | — | US | disclosed |
| US-4120889-A | Cyano ethynylbenzene compounds | WILLIAM H. RORER, INC. (US) | 1978-10-17 | — | — | US | disclosed |
| US-4120885-A | Ethynylbenzene compounds and derivatives thereof | WILLIAM H. RORER, INC. (US) | 1978-10-17 | — | — | US | disclosed |
| US-4105786-A | ANTIINFLAMMATORY | WILLIAM H. RORER, INC. (US) | 1978-08-08 | — | — | US | disclosed |
| US-4101591-A | Ethynylbenzene compounds and derivatives thereof | WILLIAM H. RORER, INC. (US) | 1978-07-18 | — | — | US | disclosed |
| US-4096279-A | Ethynylbenzene compounds and derivatives thereof in the treatment of pain fever and inflammation | WILLIAM H. RORER, INC. (US) | 1978-06-20 | — | — | US | disclosed |
| US-4094995-A | ETHYNYLBENZENE COMPOUNDS AND DERIVATIVES THEREOF TO TREAT PAIN, FEVER AND INFLAMMATION | WILLIAM H. RORER, INC. (US) | 1978-06-13 | — | — | US | disclosed |
| US-4093737-A | Ethynylbenzene compounds and derivatives thereof in the treatment of pain, fever or inflammation | WILLIAM H. RORER, INC. (US) | 1978-06-06 | — | — | US | disclosed |
| US-4075354-A | ETHYNYLBENZENE COMPOUNDS AND DERIVATIVES THEREOF FOR TREATING PAIN FEVER AND INFLAMMATION | WILLIAM H. RORER, INC. (US) | 1978-02-21 | — | — | US | disclosed |
| US-3981932-A | Ethynylbenzene compounds and derivatives thereof | WILLIAM H. RORER, INC. (US) | 1976-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095124-A1 | BASE AND RADICAL GENERATOR, COMPOSITION USING SAME AND METHOD FOR CURING SAME | SRM, ARG2, SQOR | MAPT 4266/4885LMNA 1871/4885NPC1 4855/4885 |
| US-20090075989-A1 | NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS | NR5A1, CYP19A1, GPER1 | MAPT 4871/4885LMNA 2272/4885NPC1 3356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.