Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PRNP | P04156 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9405959 | 0.87 | AR (0.45) | ARCYP11B1CYP11B2XDHKDM4E | |
| SCHEMBL1579020 | 0.79 | AR (0.47) | ARCYP11B1CYP11B2KDM4ELMNA | |
| SCHEMBL13485290 | 0.77 | AR (0.49) | ARCYP11B1CYP11B2XDHCYP1A2 | |
| SCHEMBL1405776 | 0.77 | LMNA (0.47) | ARCYP11B1CYP11B2KDM4ELMNA | |
| SCHEMBL9723142 | 0.76 | ALDH1A1 (0.44) | ARCYP11B1CYP11B2XDHKDM4E | |
| SCHEMBL17028248 | 0.76 | CYP11B1 (0.40) | ARCYP11B1CYP11B2KDM4ELMNA | |
| SCHEMBL27851238 | 0.76 | KDM4E (0.40) | ARCYP11B1CYP11B2KDM4ELMNA | |
| SCHEMBL7508041 | 0.75 | AR (0.43) | ARKDM4ELMNACYP1A2CYP3A4 | |
| SCHEMBL14190820 | 0.74 | ALDH1A1 (0.44) | KDM4ELMNACYP1A2CYP2C19TUBB1 | |
| SCHEMBL10138488 | 0.74 | TUBB1 (0.40) | KDM4ECYP1A2CYP2C9CYP2C19TUBB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8658620-B2 | Pharmaceutical composition, use of 2-iminopyrrolidine derivative for production of pharmaceutical composition, and kit for treatment or amelioration of heart diseases | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2014-02-25 | — | — | US | disclosed |
| US-8658620-B2 | Pharmaceutical composition, use of 2-iminopyrrolidine derivative for production of pharmaceutical composition, and kit for treatment or amelioration of heart diseases | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2014-02-25 | — | — | US | disclosed |
| US-8658620-B2 | Pharmaceutical composition, use of 2-iminopyrrolidine derivative for production of pharmaceutical composition, and kit for treatment or amelioration of heart diseases | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2014-02-25 | — | — | US | disclosed |
| EP-2241315-B1 | PHARMACEUTICAL COMPOSITION, USE OF 2-IMINOPYRROLIDINE DERIVATIVE FOR PRODUCTION OF PHARMACEUTICAL COMPOSITION, AND KIT FOR TREATMENT OR AMELIORATION OF HEART DISEASES | EISAI R&D MAN CO LTD (JP) | 2013-12-11 | — | — | EP | disclosed |
| EP-2444393-A1 | Methods for producing cyclic benzamidine derivatives | Eisai R&D Management Co., Ltd. (JP) | 2012-04-25 | — | — | EP | disclosed |
| EP-2444393-A1 | Methods for producing cyclic benzamidine derivatives | Eisai R&D Management Co., Ltd. (JP) | 2012-04-25 | — | — | EP | disclosed |
| US-20100286087-A1 | PHARMACEUTICAL COMPOSITION, USE OF 2-IMINOPYRROLIDINE DERIVATIVE FOR PRODUCTION OF PHARMACEUTICAL COMPOSITION, AND KIT FOR TREATMENT OR AMELIORATION OF HEART DISEASES | EISAI R&D MANAGEMENT CO, LTD. (JP) | 2010-11-11 | — | — | US | disclosed |
| US-20100286087-A1 | PHARMACEUTICAL COMPOSITION, USE OF 2-IMINOPYRROLIDINE DERIVATIVE FOR PRODUCTION OF PHARMACEUTICAL COMPOSITION, AND KIT FOR TREATMENT OR AMELIORATION OF HEART DISEASES | EISAI R&D MANAGEMENT CO, LTD. (JP) | 2010-11-11 | — | — | US | disclosed |
| US-20100286087-A1 | PHARMACEUTICAL COMPOSITION, USE OF 2-IMINOPYRROLIDINE DERIVATIVE FOR PRODUCTION OF PHARMACEUTICAL COMPOSITION, AND KIT FOR TREATMENT OR AMELIORATION OF HEART DISEASES | EISAI R&D MANAGEMENT CO, LTD. (JP) | 2010-11-11 | — | — | US | disclosed |
| EP-2241315-A1 | PHARMACEUTICAL COMPOSITION, USE OF 2-IMINOPYRROLIDINE DERIVATIVE FOR PRODUCTION OF PHARMACEUTICAL COMPOSITION, AND KIT FOR TREATMENT OR AMELIORATION OF HEART DISEASES | Eisai R&D Management Co., Ltd. (JP) | 2010-10-20 | — | — | EP | disclosed |
| EP-2241315-A1 | PHARMACEUTICAL COMPOSITION, USE OF 2-IMINOPYRROLIDINE DERIVATIVE FOR PRODUCTION OF PHARMACEUTICAL COMPOSITION, AND KIT FOR TREATMENT OR AMELIORATION OF HEART DISEASES | Eisai R&D Management Co., Ltd. (JP) | 2010-10-20 | — | — | EP | disclosed |
| US-7375236-B2 | Methods for producing cyclic benzamidine derivatives | EISAI CO., LTD. (JP) | 2008-05-20 | — | — | US | disclosed |
| US-7375236-B2 | Methods for producing cyclic benzamidine derivatives | EISAI CO., LTD. (JP) | 2008-05-20 | — | — | US | disclosed |
| US-7375236-B2 | Methods for producing cyclic benzamidine derivatives | EISAI CO., LTD. (JP) | 2008-05-20 | — | — | US | disclosed |
| US-20060058370-A1 | Methods for producing cyclic benzamidine derivatives | EISAI CO., LTD. (JP) | 2006-03-16 | — | — | US | disclosed |
| EP-1602646-A1 | PROCESSES FOR PRODUCING CYCLIC BENZAMIDINE DERIVATIVE | Eisai Co., Ltd. (JP) | 2005-12-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286087-A1 | PHARMACEUTICAL COMPOSITION, USE OF 2-IMINOPYRROLIDINE DERIVATIVE FOR PRODUCTION OF PHARMACEUTICAL COMPOSITION, AND KIT FOR TREATMENT OR AMELIORATION OF HEART DISEASES | KIT, TNNT2, TNNI3 | AR 1929/4885CYP11B1 1330/4885CYP11B2 795/4885 |
| US-20060058370-A1 | Methods for producing cyclic benzamidine derivatives | DDC, DEK, HDHD5 | AR 2088/4885CYP11B1 1747/4885CYP11B2 1329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.