Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | KDM4A | O75164 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.42 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 8/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 6/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.41 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
| ▸ | ASPH | Q12797 | 1/20 | 0.40 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10464802 | 0.85 | KDM4E (0.48) | KDM4EKDM4AL3MBTL1RAB9AEGLN1 | |
| SCHEMBL15129590 | 0.79 | KDM4E (0.42) | KDM4EKDM4AL3MBTL1RAB9AEGLN1 | |
| SCHEMBL21257069 | 0.79 | KDM5B (0.50) | KDM4EKDM4AL3MBTL1RAB9AEGLN1 | |
| SCHEMBL25261318 | 0.79 | MMP2 (0.46) | KDM4EKDM4AL3MBTL1RAB9AEGLN1 | |
| SCHEMBL11669054 | 0.79 | TSHR (0.47) | KDM4EKDM4AL3MBTL1RAB9AEGLN1 | |
| SCHEMBL7031514 | 0.78 | KDM4E (0.44) | KDM4EKDM4AL3MBTL1RAB9AEGLN1 | |
| SCHEMBL18848334 | 0.77 | ALDH1A1 (0.36) | KDM4ETDP1LMNAALDH1A1MAPT | |
| SCHEMBL28012267 | 0.76 | LMNA (0.49) | KDM4EKDM4AKDM5AKDM5BKDM4C | |
| SCHEMBL28012268 | 0.76 | DHODH (0.44) | KDM4EKDM4AL3MBTL1RAB9AEGLN1 | |
| SCHEMBL30517039 | 0.74 | KDM4E (0.50) | KDM4EL3MBTL1ASPHKDM8TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250127937-A1 | FAP INHIBITOR | UNIV HEIDELBERG (DE) | 2025-04-24 | — | — | US | disclosed |
| CN-118146196-A | FAP inhibitors | 海德堡大学 | 2024-06-07 | — | — | CN | disclosed |
| US-20230112012-A1 | FAP INHIBITOR | UNIVERSITAT HEIDELBERG (DE) | 2023-04-13 | — | — | US | disclosed |
| US-20230112012-A1 | FAP INHIBITOR | UNIVERSITAT HEIDELBERG (DE) | 2023-04-13 | — | — | US | disclosed |
| US-20210038749-A1 | FAP INHIBITOR | Universität Heidelberg (DE) | 2021-02-11 | — | — | US | disclosed |
| US-20210038749-A1 | FAP INHIBITOR | Universität Heidelberg (DE) | 2021-02-11 | — | — | US | disclosed |
| EP-3749663-A1 | FAP INHIBITOR | Universität Heidelberg (DE) | 2020-12-16 | — | — | EP | disclosed |
| CN-111699181-A | FAP inhibitors | 海德堡大学 | 2020-09-22 | — | — | CN | disclosed |
| WO-2019154859-A1 | FAP INHIBITOR | Universität Heidelberg (DE) | 2019-08-15 | — | — | WO | disclosed |
| WO-2019154859-A1 | FAP INHIBITOR | Universität Heidelberg (DE) | 2019-08-15 | — | — | WO | disclosed |
| WO-2019154886-A1 | FAP INHIBITOR | Universität Heidelberg (DE) | 2019-08-15 | — | — | WO | disclosed |
| WO-2019154886-A1 | FAP INHIBITOR | Universität Heidelberg (DE) | 2019-08-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210038749-A1 | FAP INHIBITOR | FAP, APC, FIBP | KDM4E 2204/4885KDM4A 2408/4885L3MBTL1 4669/4885 |
| US-20250127937-A1 | FAP INHIBITOR | FAP, APC, FIBP | KDM4E 2204/4885KDM4A 2408/4885L3MBTL1 4669/4885 |
| US-20230112012-A1 | FAP INHIBITOR | FAP, APC, FIBP | KDM4E 2204/4885KDM4A 2408/4885L3MBTL1 4669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.