Methylmalonic Acid

Methylmalonic Acid

SCHEMBL21273765

CC(C(=O)O)C(=O)O.[KH].c1ccc2c(c1)C2

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.41
PTGS2 P35354 1/20 0.39
LMNA P02545 1/20 0.39
MAPT P10636 1/20 0.39
XBP1 P17861 1/20 0.39
ATM Q13315 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
SRD5A2 P31213 1/20 0.39
DRD2 P14416 1/20 0.39
DRD1 P21728 1/20 0.39
DRD4 P21917 1/20 0.39
DRD5 P21918 1/20 0.39
DRD3 P35462 1/20 0.39
GRM7 Q14831 2/20 0.39
HTR2A P28223 1/20 0.38
CYP2D6 P10635 1/20 0.38
SRC P12931 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Alanine SCHEMBL16899299 0.81 HTR2A (0.46) CYP1A2PTGS2SRD5A2GRM7HTR2A
SCHEMBL5167058 0.79 AAK1 (0.38) LMNAMAPTATMGRM7
Bicarbonate SCHEMBL8601125 0.78 CYP1A2 (0.55) CYP1A2SRD5A2DRD2DRD1DRD4
SCHEMBL6982942 0.78 HTT (0.42) LMNAMAPTSMN1; SMN2GRM7
Methylmalonic Acid SCHEMBL28727401 0.77 CYP1A2 (0.39) CYP1A2LMNAMAPTXBP1ATM
Fluorene SCHEMBL28524054 0.77 SRD5A2 (0.55) CYP1A2LMNAMAPTSMN1; SMN2SRD5A2
Biphenyl SCHEMBL28073453 0.77 PTGS2 (0.61) CYP1A2PTGS2MAPTSMN1; SMN2
Biphenyl SCHEMBL1774586 0.77 PTGS2 (0.61) CYP1A2PTGS2MAPTSMN1; SMN2
Naphthalene SCHEMBL8164671 0.77 LMNA (0.45) PTGS2LMNAMAPTXBP1ATM
Threonine SCHEMBL567434 0.76 HTR2A (0.42) CYP1A2LMNAHTR2ACYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11180630-B2 Metal salts of malonic acid as nucleating additives for crystalline thermoplastics INDIAN OIL CORPORATION LIMITED (IN) 2021-11-23 US disclosed
US-20190256683-A1 METAL SALTS OF MALONIC ACID AS NUCLEATING ADDITIVES FOR CRYSTALLINE THERMOPLASTICS INDIAN OIL CORPORATION LIMITED (IN) 2019-08-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190256683-A1 METAL SALTS OF MALONIC ACID AS NUCLEATING ADDITIVES FOR CRYSTALLINE THERMOPLASTICS NUMA1, MNS1, ME1 CYP1A2 3601/4885PTGS2 3452/4885LMNA 1307/4885
US-11180630-B2 Metal salts of malonic acid as nucleating additives for crystalline thermoplastics NUMA1, MNS1, ME1 CYP1A2 3601/4885PTGS2 3452/4885LMNA 1307/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.