Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 7/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | CTSV | O60911 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | CTSC | P53634 | 1/20 | 0.37 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.37 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL745471 | 1.00 | SIGMAR1 (0.41) | SIGMAR1MEN1ALDH1A1KMT2ATACR1 | |
| SCHEMBL745470 | 1.00 | SIGMAR1 (0.41) | SIGMAR1MEN1ALDH1A1KMT2ATACR1 | |
| SCHEMBL1426284 | 0.76 | OPRM1 (0.42) | SIGMAR1ALDH1A1TACR1SLC18A3KLK7 | |
| SCHEMBL3675920 | 0.76 | KMT2A (0.51) | KMT2AKLK7CTSLCTSBCTSK | |
| SCHEMBL10281391 | 0.76 | KMT2A (0.51) | KMT2AKLK7CTSLCTSBCTSK | |
| SCHEMBL12209029 | 0.76 | KMT2A (0.51) | KMT2AKLK7CTSLCTSBCTSK | |
| SCHEMBL743818 | 0.75 | CTSL (0.45) | SIGMAR1MEN1ALDH1A1KMT2ASLC18A3 | |
| SCHEMBL743817 | 0.75 | CTSL (0.45) | SIGMAR1MEN1ALDH1A1KMT2ASLC18A3 | |
| SCHEMBL14917502 | 0.75 | CTSL (0.45) | SIGMAR1MEN1ALDH1A1KMT2ASLC18A3 | |
| SCHEMBL743816 | 0.75 | CTSL (0.45) | SIGMAR1MEN1ALDH1A1KMT2ASLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565436-B1 | 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORP (US) | 2012-04-25 | — | — | EP | disclosed |
| US-7834021-B2 | 3-aminopyrrolidine derivatives as modulators of chemokine receptors | INCYTE CORPORATION (US) | 2010-11-16 | — | — | US | disclosed |
| US-20060252751-A1 | 3-Aminopyrrolidine derivaties as modulators of chemokine receptors | INCYTE HOLDINGS CORPORATION | 2006-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252751-A1 | 3-Aminopyrrolidine derivaties as modulators of chemokine receptors | CCR2, CXCR3, CCR5 | SIGMAR1 282/4885MEN1 4347/4885ALDH1A1 2501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.