SCHEMBL2127382

SCHEMBL2127382

O=C(O)COc1ccc(F)c2c(=O)c3ccccc3sc12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 5/20 0.49
PTPN2 P17706 1/20 0.49
PTPRC P08575 1/20 0.43
PTPRF P10586 1/20 0.43
PTPRA P18433 1/20 0.43
PTPRB P23467 1/20 0.43
PTPN6 P29350 1/20 0.43
DUSP3 P51452 1/20 0.43
PTPN12 Q05209 1/20 0.43
HPGD P15428 2/20 0.42
ALDH1A1 P00352 2/20 0.42
KDM4E B2RXH2 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
PTGDR2 Q9Y5Y4 2/20 0.40
MAPT P10636 2/20 0.40
NPC1 O15118 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6491767 0.86 PTPN1 (0.50) PTPN1PTPN2PTPRCPTPRFPTPRA
SCHEMBL30080217 0.85 PTPN1 (0.49) PTPN1PTPN2PTPRCPTPRFPTPRA
SCHEMBL2126462 0.85 PTPN1 (0.49) PTPN1PTPN2PTPRCPTPRFPTPRA
SCHEMBL16785829 0.85 F9 (0.46) PTPN1HPGDALDH1A1KDM4EMAPT
SCHEMBL8413609 0.84 PTPN1 (0.48) PTPN1PTPN2PTPRCPTPRFPTPRA
SCHEMBL15097124 0.84 HPGD (0.36) PTPN1PTPN2HPGDALDH1A1KDM4E
SCHEMBL2763154 0.84 NPC1 (0.40) HPGDMAPTNPC1CYP1A2CYP3A4
SCHEMBL6483685 0.83 HPGD (0.51) PTPN1PTPN2PTPRCPTPRFPTPRA
SCHEMBL16785830 0.82 RAB9A (0.34) PTPN1PTPN2HPGDKDM4ETDP1
SCHEMBL15097122 0.82 MAOA (0.36) PTPN1PTPN2HPGDALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2444429-B1 LED CURABLE COMPOSITIONS AGFA GRAPHICS NV (BE) 2016-09-07 EP disclosed
EP-2447259-B1 Polymerisable photoinitiators for LED curable compositions AGFA GRAPHICS NV (BE) 2016-03-16 EP disclosed
US-8985753-B2 LED curable compositions AGFA GRAPHICS NV (BE) 2015-03-24 US disclosed
US-8985753-B2 LED curable compositions AGFA GRAPHICS NV (BE) 2015-03-24 US disclosed
US-8985753-B2 LED curable compositions AGFA GRAPHICS NV (BE) 2015-03-24 US disclosed
US-8759412-B2 Polymerisable photoinitiators for LED curable compositions AGFA GRAPHICS NV (BE) 2014-06-24 US disclosed
US-8759412-B2 Polymerisable photoinitiators for LED curable compositions AGFA GRAPHICS NV (BE) 2014-06-24 US disclosed
US-8759412-B2 Polymerisable photoinitiators for LED curable compositions AGFA GRAPHICS NV (BE) 2014-06-24 US disclosed
US-20130210954-A1 POLYMERISABLE PHOTOINITIATORS FOR LED CURABLE COMPOSITIONS AGFA-GEVAERT N.V. (BE) 2013-08-15 US disclosed
US-20130210954-A1 POLYMERISABLE PHOTOINITIATORS FOR LED CURABLE COMPOSITIONS AGFA-GEVAERT N.V. (BE) 2013-08-15 US disclosed
US-20130210954-A1 POLYMERISABLE PHOTOINITIATORS FOR LED CURABLE COMPOSITIONS AGFA-GEVAERT N.V. (BE) 2013-08-15 US disclosed
US-20130176370-A1 LED CURABLE COMPOSITIONS AGFA-GEVAERT N.V. (BE) 2013-07-11 US disclosed
US-20130176370-A1 LED CURABLE COMPOSITIONS AGFA-GEVAERT N.V. (BE) 2013-07-11 US disclosed
US-20130176370-A1 LED CURABLE COMPOSITIONS AGFA-GEVAERT N.V. (BE) 2013-07-11 US disclosed
EP-2447259-A1 Polymerisable photoinitiators for LED curable compositions Agfa-Gevaert (BE) 2012-05-02 EP disclosed
WO-2012052291-A1 LED CURABLE COMPOSITIONS AGFA-GEVAERT (BE) 2012-04-26 WO disclosed
WO-2012052288-A1 POLYMERISABLE PHOTOINITIATORS FOR LED CURABLE COMPOSITIONS AGFA-GEVAERT (BE) 2012-04-26 WO disclosed
EP-2444429-A1 Led curable compositions Agfa-Gevaert (BE) 2012-04-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130210954-A1 POLYMERISABLE PHOTOINITIATORS FOR LED CURABLE COMPOSITIONS ADSL, ALAD, ACSL3 PTPN1 4019/4885PTPN2 4034/4885PTPRC 4412/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.