Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | GPR139 | Q6DWJ6 | 5/20 | 0.60 |
| ▸ | GPR132 | Q9UNW8 | 2/20 | 0.60 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.59 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.59 |
| ▸ | MMP2 | P08253 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.55 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21274453 | 1.00 | NPC1 (0.60) | NPC1RAB9AGPR139GPR132TAS1R3 | |
| SCHEMBL11510357 | 0.87 | ALDH1A1 (0.64) | NPC1RAB9AGPR139GPR132SMN1; SMN2 | |
| SCHEMBL21274338 | 0.87 | TAS1R3 (0.61) | NPC1RAB9AGPR139TAS1R3TAS1R1 | |
| SCHEMBL21274340 | 0.87 | TAS1R3 (0.61) | NPC1RAB9AGPR139TAS1R3TAS1R1 | |
| SCHEMBL4177361 | 0.85 | GPR139 (0.70) | NPC1RAB9AGPR139GPR132TAS1R3 | |
| SCHEMBL381132 | 0.85 | TAS1R3 (0.68) | NPC1RAB9AGPR139TAS1R3TAS1R1 | |
| SCHEMBL30098882 | 0.85 | TAS1R3 (0.68) | NPC1RAB9AGPR139TAS1R3TAS1R1 | |
| SCHEMBL31389153 | 0.84 | TAS1R3 (0.61) | NPC1RAB9AGPR139TAS1R3TAS1R1 | |
| SCHEMBL13753418 | 0.84 | TAS1R3 (0.63) | NPC1RAB9AGPR139TAS1R3TAS1R1 | |
| SCHEMBL7410707 | 0.82 | NPSR1 (0.71) | TAS1R3TAS1R1MMP2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230257388-A1 | GRANZYME B DIRECTED IMAGING AND THERAPY | CYTOSITE BIOPHARMA INC. (US) | 2023-08-17 | — | — | US | disclosed |
| US-11667645-B2 | Granzyme B directed imaging and therapy | CYTOSITE BIOPHARMA INC. (US) | 2023-06-06 | — | — | US | disclosed |
| CN-113968795-A | Compound, composition and application of compound and composition in preparation of medicine with effect of treating myocarditis | 潍坊市人民医院(潍坊市传染病医院) | 2022-01-25 | — | — | CN | disclosed |
| CN-112261939-A | Granzyme B directed imaging and therapy | 塞托赛特生物制药股份有限公司 | 2021-01-22 | — | — | CN | disclosed |
| EP-3752145-A1 | GRANZYME B DIRECTED IMAGING AND THERAPY | Cytosite Biopharma Inc. (US) | 2020-12-23 | — | — | EP | disclosed |
| US-20200369673-A1 | GRANZYME B DIRECTED IMAGING AND THERAPY | CYTOSITE BIOPHARMA INC. | 2020-11-26 | — | — | US | disclosed |
| WO-2019160916-A1 | GRANZYME B DIRECTED IMAGING AND THERAPY | CYTOSITE BIOPHARMA INC. (US) | 2019-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230257388-A1 | GRANZYME B DIRECTED IMAGING AND THERAPY | GZMB, PRF1, CTSB | NPC1 1424/4885RAB9A 1343/4885GPR139 1219/4885 |
| US-20200369673-A1 | GRANZYME B DIRECTED IMAGING AND THERAPY | GZMB, PRF1, CTSB | NPC1 1424/4885RAB9A 1343/4885GPR139 1219/4885 |
| US-11667645-B2 | Granzyme B directed imaging and therapy | GZMB, PRF1, CTSB | NPC1 1424/4885RAB9A 1343/4885GPR139 1219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.