SCHEMBL2127535

SCHEMBL2127535

Nc1ccc(NC(=O)c2ccccc2N)cc1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 2/20 0.69
FADS1 O60427 3/20 0.63
MEN1 O00255 4/20 0.58
KMT2A Q03164 4/20 0.58
LMNA P02545 4/20 0.58
TDP1 Q9NUW8 2/20 0.58
POLB P06746 1/20 0.58
PKM P14618 1/20 0.58
APEX1 P27695 1/20 0.58
P2RX1 P51575 1/20 0.58
RAB9A P51151 5/20 0.54
NPC1 O15118 4/20 0.54
ALDH1A1 P00352 3/20 0.54
KDM4E B2RXH2 2/20 0.54
MAPT P10636 2/20 0.53
MAOB P27338 1/20 0.52
GFER P55789 1/20 0.51
PRMT1 Q99873 1/20 0.51
TP53 P04637 1/20 0.50
HPGD P15428 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30830441 1.00 PTGS1 (0.69) PTGS1FADS1MEN1KMT2ALMNA
SCHEMBL17744848 0.94 PTGS1 (0.75) PTGS1FADS1MEN1KMT2ALMNA
SCHEMBL17744771 0.93 POLB (0.71) PTGS1FADS1MEN1KMT2ALMNA
SCHEMBL8402954 0.90 KMT2A (0.64) PTGS1MEN1KMT2ALMNATDP1
SCHEMBL1140055 0.89 PTGS1 (0.68) PTGS1FADS1MEN1KMT2ALMNA
SCHEMBL4954215 0.87 PTGS1 (0.67) PTGS1FADS1MEN1KMT2ALMNA
SCHEMBL4957349 0.87 LMNA (0.69) PTGS1FADS1MEN1KMT2ALMNA
SCHEMBL5853941 0.86 PTGS1 (0.65) PTGS1FADS1MEN1KMT2ALMNA
SCHEMBL15361168 0.86 SMN1; SMN2 (0.68) PTGS1FADS1MEN1KMT2ALMNA
SCHEMBL1961988 0.86 FADS1 (0.73) PTGS1FADS1MEN1KMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220011485-A1 CURABLE COMPOSITION, LIGHT-SHIELDING FILM, COLOR FILTER, PATTERN FORMING METHOD, METHOD FOR MANUFACTURING COLOR FILTER, SOLID-STATE IMAGING ELEMENT, AND INFRARED SENSOR FUJIFILM CORPORATION (JP) 2022-01-13 US disclosed
US-11156754-B2 Curable composition, light-shielding film, color filter, pattern forming method, method for manufacturing color filter, solid-state imaging element, and infrared sensor FUJIFILM CORPORATION (JP) 2021-10-26 US disclosed
US-10752624-B2 Kinase inhibitors ORIGENIS GMBH (DE) 2020-08-25 US disclosed
US-10209554-B2 Method for manufacturing laminated resin black-matrix substrate TORAY INDUSTRIES, INC. (JP) 2019-02-19 US disclosed
US-20190018174-A1 CURABLE COMPOSITION, LIGHT-SHIELDING FILM, COLOR FILTER, PATTERN FORMING METHOD, METHOD FOR MANUFACTURING COLOR FILTER, SOLID-STATE IMAGING ELEMENT, AND INFRARED SENSOR FUJIFILM CORPORATION (JP) 2019-01-17 US disclosed
US-20180305356-A1 NOVEL KINASE INHIBITORS ORIGENIS GMBH (DE) 2018-10-25 US disclosed
US-10000482-B2 Kinase inhibitors ORIGENIS GMBH (DE) 2018-06-19 US disclosed
US-9637491-B2 Pyrazolo[4,3-D]pyrimidines as kinase inhibitors ORIGENIS GMBH (DE) 2017-05-02 US disclosed
EP-2444376-B1 BLACK COMPOSITE PARTICLE, BLACK RESIN COMPOSITION, COLOR FILTER SUBSTRATE AND LIQUID CRYSTAL DISPLAY TORAY INDUSTRIES (JP) 2017-01-25 EP disclosed
US-20160370646-A1 METHOD FOR MANUFACTURING LAMINATED RESIN BLACK-MATRIX SUBSTRATE TORAY INDUSTRIES, INC. (JP) 2016-12-22 US disclosed
WO-2014060112-A1 PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2014-04-24 WO disclosed
WO-2014060113-A1 NOVEL KINASE INHIBITORS ORIGENIS GMBH (DE) 2014-04-24 WO disclosed
US-8329068-B2 Black resin composition, resin black matrix, color filter and liquid crystal display TORAY INDUSTRIES, INC. (JP) 2012-12-11 US disclosed
US-20120128898-A1 BLACK COMPOSITE PARTICLE, BLACK RESIN COMPOSITION, COLOR FILTER SUBSTRATE AND LIQUID CRYSTAL DISPLAY TORAY INDUSTRIES, INC. (JP) 2012-05-24 US disclosed
EP-2444376-A1 BLACK COMPOSITE PARTICLE, BLACK RESIN COMPOSITION, COLOR FILTER SUBSTRATE AND LIQUID CRYSTAL DISPLAY Toray Industries, Inc. (JP) 2012-04-25 EP disclosed
US-20100038606-A1 BLACK RESIN COMPOSITION, RESIN BLACK MATRIX, COLOR FILTER AND LIQUID CRYSTAL DISPLAY TORAY INDUSTRIES, INC. (JP) 2010-02-18 US disclosed
EP-2135900-A1 BLACK RESIN COMPOSITION, RESIN BLACK MATRIX, COLOR FILTER AND LIQUID CRYSTAL DISPLAY Toray Industries, Inc. (JP) 2009-12-23 EP disclosed
US-20030036653-A1 Diaminopyridine-containing thiourea inhibitors of herpes viruses AMERICAN HOME PRODUCTS CORPORATION 2003-02-20 US disclosed
US-20020026055-A1 Aminopyridine-containing thiourea inhibitors of herpes viruses AMERICAN HOME PRODUCTS CORPORATION 2002-02-28 US disclosed
US-20010039348-A1 Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group AMERICAN HOME PRODUCTS CORPORATION (US) 2001-11-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180305356-A1 NOVEL KINASE INHIBITORS LRRK2, MYLK2, MYLK PTGS1 2100/4885FADS1 4381/4885MEN1 544/4885
US-20030036653-A1 Diaminopyridine-containing thiourea inhibitors of herpes viruses HAVCR2, CCR6, CXCR6 PTGS1 4336/4885FADS1 4455/4885MEN1 4810/4885
US-20010039348-A1 Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group CCR6, HAVCR2, BCOR PTGS1 3433/4885FADS1 4390/4885MEN1 4755/4885
US-20020026055-A1 Aminopyridine-containing thiourea inhibitors of herpes viruses TK1, TPMT, CXCR6 PTGS1 3088/4885FADS1 4786/4885MEN1 4601/4885
US-10000482-B2 Kinase inhibitors LRRK2, MYLK2, MYLK PTGS1 1996/4885FADS1 4412/4885MEN1 636/4885
US-10752624-B2 Kinase inhibitors LRRK2, MYLK2, MYLK PTGS1 1996/4885FADS1 4412/4885MEN1 636/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.