Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 10/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.62 |
| ▸ | TSHR | P16473 | 8/20 | 0.62 |
| ▸ | USP2 | O75604 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21276239 | 0.88 | FAAH (0.47) | CYP2D6CYP3A4TSHRUSP2ALDH1A1 | |
| SCHEMBL21276143 | 0.87 | FAAH (0.50) | — | |
| SCHEMBL20558039 | 0.87 | USP2 (0.46) | CYP2D6CYP3A4TSHRUSP2ALDH1A1 | |
| SCHEMBL21276255 | 0.86 | FAAH (0.53) | — | |
| SCHEMBL17276615 | 0.85 | ALDH1A1 (0.54) | TSHRUSP2ALDH1A1SMN1; SMN2 | |
| SCHEMBL21276225 | 0.84 | FAAH (0.46) | CYP2D6CYP3A4TSHRUSP2ALDH1A1 | |
| SCHEMBL21276335 | 0.84 | CYP3A4 (0.56) | CYP2D6CYP3A4TSHRUSP2ALDH1A1 | |
| SCHEMBL20556800 | 0.83 | — | — | |
| SCHEMBL21276318 | 0.82 | CYP3A4 (0.51) | CYP2D6CYP3A4TSHRUSP2CYP1A2 | |
| SCHEMBL21257996 | 0.81 | MGLL (0.50) | CYP2D6CYP3A4TSHRUSP2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10385057-B2 | Pyrazole compounds and methods of making and using same | LUNDBECK LA JOLLA RESEARCH CENTER, INC. (US) | 2019-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10385057-B2 | Pyrazole compounds and methods of making and using same | FAAH, FAAH2, MGLL | CYP2D6 114/4885CYP3A4 193/4885TSHR 4145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.