Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.53 |
| ▸ | CA12 | O43570 | 4/20 | 0.53 |
| ▸ | CA1 | P00915 | 4/20 | 0.53 |
| ▸ | CA7 | P43166 | 4/20 | 0.53 |
| ▸ | CA9 | Q16790 | 4/20 | 0.53 |
| ▸ | CA13 | Q8N1Q1 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | CASP1 | P29466 | 3/20 | 0.53 |
| ▸ | CASP7 | P55210 | 3/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31169352 | 0.75 | MCL1 (1.00) | MCL1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL5085582 | 0.75 | MCL1 (1.00) | MCL1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL2265895 | 0.74 | CA9 (0.49) | MCL1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL73415 | 0.74 | LMNA (0.58) | ALDH1A1HPGDKDM4EHSD17B10CA12 | |
| SCHEMBL4420514 | 0.73 | ALDH1A1 (0.45) | ALDH1A1HPGDKDM4EHSD17B10CA1 | |
| SCHEMBL28417210 | 0.71 | CYP3A4 (0.47) | ALDH1A1KDM4ECA12CA9MAPT | |
| SCHEMBL28605152 | 0.70 | ADORA3 (0.65) | MCL1KDM4ECA12CA1CA7 | |
| SCHEMBL29577455 | 0.70 | KDM4E (0.64) | HPGDKDM4EHSD17B10MAPTALOX15 | |
| SCHEMBL28903666 | 0.70 | KDM4E (0.64) | HPGDKDM4EHSD17B10MAPTALOX15 | |
| SCHEMBL29577293 | 0.70 | KDM4E (0.64) | HPGDKDM4EHSD17B10MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170020840-A1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | BIONOMICS LTD (AU) | 2017-01-26 | — | — | US | disclosed |
| US-9346842-B2 | Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors | BIONOMICS LIMITED (AU) | 2016-05-24 | — | — | US | disclosed |
| US-20140171642-A1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | BIONOMICS LIMITED (AU) | 2014-06-19 | — | — | US | disclosed |
| US-8716335-B2 | Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors | BIONOMICS LIMITED (AU) | 2014-05-06 | — | — | US | disclosed |
| US-8680135-B2 | Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors | BIONOMICS LIMITED (AU) | 2014-03-25 | — | — | US | disclosed |
| US-20130053351-A1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | BIONOMICS LIMITED (AU) | 2013-02-28 | — | — | US | disclosed |
| US-20120214770-A1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | BIONOMICS LIMITED (AU) | 2012-08-23 | — | — | US | disclosed |
| US-8198466-B2 | Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors | BIONOMICS LIMITED (AU) | 2012-06-12 | — | — | US | disclosed |
| EP-2460793-A1 | Substituted Benzofurans, Benzothiophenes, Benzoselenophenes and Indoles And Their Use as Tubulin Polymerisation Inhibitors | Bionomics Limited (AU) | 2012-06-06 | — | — | EP | disclosed |
| EP-1984333-B1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | BIONOMICS LTD (AU) | 2012-04-25 | — | — | EP | disclosed |
| US-20100004208-A1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | BIONOMICS LIMITED (AU) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214770-A1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | TUBB1, TUBB3, TUBB | MCL1 1561/4885ALDH1A1 1904/4885HPGD 3766/4885 |
| US-20170020840-A1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | TUBB1, TUBB3, TUBB | MCL1 1561/4885ALDH1A1 1904/4885HPGD 3766/4885 |
| US-20100004208-A1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | TUBB1, TUBB3, TUBB | MCL1 1561/4885ALDH1A1 1904/4885HPGD 3766/4885 |
| US-20140171642-A1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | TUBB1, TUBB3, TUBB | MCL1 1561/4885ALDH1A1 1904/4885HPGD 3766/4885 |
| US-20130053351-A1 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS | TUBB1, TUBB3, TUBB | MCL1 1561/4885ALDH1A1 1904/4885HPGD 3766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.