Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 5/20 | 0.36 |
| ▸ | LPL | P06858 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23287138 | 0.86 | SMN1; SMN2 (0.43) | DGAT1GSK3AGSK3BUCHL1LIPG | |
| SCHEMBL16737528 | 0.79 | CYP4F2 (0.42) | DGAT1GSK3AGSK3BCYP4F2CYP4A11 | |
| SCHEMBL67865 | 0.78 | LIPG (0.59) | CYP4F2CYP4A11UCHL1LIPGLPL | |
| SCHEMBL2182388 | 0.78 | DGAT1 (0.42) | DGAT1GSK3AGSK3BUCHL1SMN1; SMN2 | |
| SCHEMBL28697197 | 0.78 | DGAT1 (0.43) | DGAT1GSK3AGSK3BUCHL1LIPG | |
| SCHEMBL2181713 | 0.77 | DGAT1 (0.39) | DGAT1GSK3AGSK3BUCHL1LIPG | |
| SCHEMBL18274843 | 0.75 | DGAT1 (0.47) | DGAT1GSK3AGSK3BUCHL1LIPG | |
| SCHEMBL4206551 | 0.75 | DGAT1 (0.49) | DGAT1GSK3AGSK3BUCHL1LIPG | |
| SCHEMBL15298112 | 0.74 | FFAR1 (0.52) | DGAT1GSK3AGSK3BUCHL1SMN1; SMN2 | |
| SCHEMBL22845610 | 0.74 | DGAT1 (0.58) | DGAT1GSK3AGSK3BUCHL1LIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11008312-B2 | Pyridazine derivatives as RORc modulators | GENENTECH, INC. (US) | 2021-05-18 | — | — | US | disclosed |
| US-11008312-B2 | Pyridazine derivatives as RORc modulators | GENENTECH, INC. (US) | 2021-05-18 | — | — | US | disclosed |
| EP-3535255-A1 | PYRIDAZINE DERIVATIVES AS RORC MODULATORS | H. Hoffnabb-La Roche Ag (CH) | 2019-09-11 | — | — | EP | disclosed |
| US-20190263794-A1 | PYRIDAZINE DERIVATIVES AS RORc MODULATORS | GENENTECH, INC. (US) | 2019-08-29 | — | — | US | disclosed |
| US-20190263794-A1 | PYRIDAZINE DERIVATIVES AS RORc MODULATORS | GENENTECH, INC. (US) | 2019-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11008312-B2 | Pyridazine derivatives as RORc modulators | RORC, RORB, RORA | DGAT1 4880/4885GSK3A 1115/4885GSK3B 761/4885 |
| US-20190263794-A1 | PYRIDAZINE DERIVATIVES AS RORc MODULATORS | RORC, RORB, RORA | DGAT1 4880/4885GSK3A 1115/4885GSK3B 761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.