Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | ACR | P10323 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28891242 | 0.94 | LMNA (0.55) | LMNAALDH1A1GAAKMT2ACYP1A2 | |
| SCHEMBL8998925 | 0.84 | LMNA (0.64) | LMNAALDH1A1GAAKMT2ACYP1A2 | |
| SCHEMBL8998922 | 0.84 | LMNA (0.64) | LMNAALDH1A1GAAKMT2ACYP1A2 | |
| SCHEMBL8166082 | 0.84 | LMNA (0.64) | LMNAALDH1A1GAAKMT2ACYP1A2 | |
| SCHEMBL39792 | 0.80 | THRB (0.59) | LMNAALDH1A1GAAKMT2ACYP1A2 | |
| SCHEMBL8858845 | 0.79 | KMT2A (0.46) | GAAKMT2AHTTMEN1TDP1 | |
| SCHEMBL28711842 | 0.78 | LMNA (0.57) | LMNAALDH1A1GAAKMT2ACYP1A2 | |
| SCHEMBL27701665 | 0.78 | THRB (0.58) | LMNAALDH1A1GAAKMT2ACYP1A2 | |
| Hydrochloric Acid SCHEMBL19749007 | 0.78 | THRB (0.58) | LMNAALDH1A1GAAKMT2ACYP1A2 | |
| SCHEMBL27464290 | 0.78 | LMNA (0.57) | LMNAALDH1A1GAAKMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10597381-B2 | Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-03-24 | — | — | US | disclosed |
| US-20190135782-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2019-05-09 | — | — | US | disclosed |
| US-9580398-B2 | Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-02-28 | — | — | US | disclosed |
| US-8513180-B2 | Ethanol-free perfume oil microemulsion | SYMRISE AG (DE) | 2013-08-20 | — | — | US | disclosed |
| US-20120101020-A1 | ETHANOL-FREE PERFUME OIL MICROEMULSION | SYMRISE AG (DE) | 2012-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10597381-B2 | Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders | AIFM2, GPX1, GPX4 | LMNA 1554/4885ALDH1A1 1311/4885GAA 685/4885 |
| US-20120101020-A1 | ETHANOL-FREE PERFUME OIL MICROEMULSION | FFAR2, FFAR3, FFAR1 | LMNA 4328/4885ALDH1A1 226/4885GAA 3892/4885 |
| US-20190135782-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS | AIFM2, GPX1, GPX4 | LMNA 1554/4885ALDH1A1 1311/4885GAA 685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.