Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.46 |
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.46 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA3 | P07451 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL361493 | 0.97 | — | — | |
| SCHEMBL489665 | 0.94 | PTGS1 (0.46) | PTGS1PDE4ALMNASLC6A6CYP2C19 | |
| Ammonia Solution, Strong SCHEMBL15643579 | 0.94 | PTGS1 (0.46) | PTGS1PDE4ALMNASLC6A6CYP2C19 | |
| SCHEMBL30018569 | 0.94 | PTGS1 (0.46) | PTGS1PDE4ALMNASLC6A6CYP2C19 | |
| Potassium SCHEMBL29855512 | 0.94 | PTGS1 (0.46) | PTGS1PDE4ALMNASLC6A6CYP2C19 | |
| Propene SCHEMBL27830357 | 0.87 | PTGS1 (0.40) | PTGS1PDE4ALMNASLC6A6CYP2C19 | |
| SCHEMBL30579953 | 0.85 | PTGS1 (0.39) | PTGS1PDE4ALMNASLC6A6CYP2C19 | |
| Water SCHEMBL21226523 | 0.84 | APP (0.44) | PTGS1PDE4ALMNASLC6A6CYP2C19 | |
| Acrylonitrile SCHEMBL30729961 | 0.83 | ALDH1A1 (0.35) | PTGS1PDE4AALDH1A1TSHR | |
| Water SCHEMBL30397698 | 0.82 | APP (0.42) | PTGS1PDE4ALMNASLC6A6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12582752-B2 | Medical device and method for manufacturing same | TERUMO KABUSHIKI KAISHA (JP) | 2026-03-24 | — | — | US | disclosed |
| US-12054564-B2 | Medical device and method for manufacturing same | TERUMO KABUSHIKI KAISHA (JP) | 2024-08-06 | — | — | US | disclosed |
| EP-4005794-B1 | MEDICAL INSTRUMENT AND METHOD FOR MANUFACTURING SAME | TERUMO CORP (JP) | 2024-07-10 | — | — | EP | disclosed |
| EP-3747479-B1 | MEDICAL INSTRUMENT | TERUMO CORP (JP) | 2024-05-29 | — | — | EP | disclosed |
| US-11872326-B2 | Medical instrument | TERUMO KABUSHIKI KAISHA (JP) | 2024-01-16 | — | — | US | disclosed |
| CN-114269400-B | Medical device and method for manufacturing the same | 泰尔茂株式会社 | 2023-12-19 | — | — | CN | disclosed |
| CN-114269399-B | Medical device and method for manufacturing the same | 泰尔茂株式会社 | 2023-09-19 | — | — | CN | disclosed |
| CN-114269401-B | Medical device and method for manufacturing the same | 泰尔茂株式会社 | 2023-07-04 | — | — | CN | disclosed |
| CN-114269402-B | Medical device and method for manufacturing the same | 泰尔茂株式会社 | 2023-06-09 | — | — | CN | disclosed |
| WO-2022202805-A1 | HYDROPHILIC COPOLYMER AND MEDICAL INSTRUMENT | テルモ株式会社 | 2022-09-29 | — | — | WO | disclosed |
| CN-114269402-A | Medical device and method of manufacturing the same | 泰尔茂株式会社 | 2022-04-01 | — | — | CN | disclosed |
| CN-114269400-A | Medical device and method of manufacturing the same | 泰尔茂株式会社 | 2022-04-01 | — | — | CN | disclosed |
| CN-114269401-A | Medical device and method of manufacturing the same | 泰尔茂株式会社 | 2022-04-01 | — | — | CN | disclosed |
| CN-114269399-A | Medical device and method of manufacturing the same | 泰尔茂株式会社 | 2022-04-01 | — | — | CN | disclosed |
| WO-2021033769-A1 | MEDICAL INSTRUMENT AND METHOD FOR MANUFACTURING SAME | テルモ株式会社 | 2021-02-25 | — | — | WO | disclosed |
| WO-2021033764-A1 | MEDICAL INSTRUMENT AND PRODUCTION METHOD THEREFOR | テルモ株式会社 | 2021-02-25 | — | — | WO | disclosed |
| WO-2021033765-A1 | MEDICAL INSTRUMENT AND METHOD FOR MANUFACTURING SAME | テルモ株式会社 | 2021-02-25 | — | — | WO | disclosed |
| WO-2021033767-A1 | MEDICAL INSTRUMENT AND MANUFACTURING METHOD THEREFOR | テルモ株式会社 | 2021-02-25 | — | — | WO | disclosed |
| WO-2021033763-A1 | MEDICAL INSTRUMENT AND METHOD FOR MANUFACTURING SAME | テルモ株式会社 | 2021-02-25 | — | — | WO | disclosed |
| WO-2019163764-A1 | MEDICAL INSTRUMENT | テルモ株式会社 | 2019-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12582752-B2 | Medical device and method for manufacturing same | STS, DEGS1, HPSE | PTGS1 171/4885PDE4A 4620/4885CHRM2 1390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.